Nano-Biomaterials
Mohammad Nazari; Razieh Solgi; Ghazale Graily; Seyed Rabi Mahdavi; Alireza Shirazi
Volume 12, Issue 1 , June 2018, , Pages 11-23
Abstract
In clinical studies, it is difficult to determine the temperature distribution throughout both tumor and normal tissue during hyperthermia treatment, since temperatures are sampled at only a limited number of locations with conventional sensors. Simulation studies can help physicians understand better ...
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In clinical studies, it is difficult to determine the temperature distribution throughout both tumor and normal tissue during hyperthermia treatment, since temperatures are sampled at only a limited number of locations with conventional sensors. Simulation studies can help physicians understand better the effects of the treatment. In this study, three 2D tumor models are built in the COMSOL software environment based on the images of nano-particle distributions in sliced PC3, DU145 and LAPC4 tumors. The images are pre-processed in MATLAB before being imported into COMSOL. A uniform distribution model is added as a control group. Temperature distribution, maximum temperature, time to reach steady state, CEM43, iso-effective dose and heat flux at tumor-tissue boundary are analyzed to evaluate the effect of the nano-particle distribution on hyperthermia treatment. The results indicate that a more concentrated nano-particle distribution is better in damaging diseased tissue than the uniform distribution under high heating power. A more uniform distribution is better than the concentrated distribution under low heating power. For concentrated nano-particle distributions, the location where the nano-particles are concentrated influences tissue damage: a more centered one has a better effect. Tumor tissue is more likely to be defective.
Bioheat Transfer
Farzan Ghalichi; Sohrab Behnia
Volume 1, Issue 1 , June 2007, , Pages 1-8
Abstract
The methods of focusing ultrasonic waves in order to apply hyperthermia cancer therapy have studied and a transducer capable of focusing waves on cancerous tissues with the aid of its piezoelectricelements has introduced. The amount of absorbed energy was computed by solving numerically the acoustic ...
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The methods of focusing ultrasonic waves in order to apply hyperthermia cancer therapy have studied and a transducer capable of focusing waves on cancerous tissues with the aid of its piezoelectricelements has introduced. The amount of absorbed energy was computed by solving numerically the acoustic pressure equation using Rayleigh-Summerfield Integral, with the intention to determine the optimum spatial array of piezoelectric elements for energy concentration. In order to control the treatment procedure, the numerical solution of Bio-heat Transfer Equation (BHTE), along with the finite-element simulation of thermal energy distribution in a cervix cancerous tissue is considered.
