Biomechanics / Biomechanical Engineering
Mehran Ashrafi; Farzan Ghalichi; Behnam Mirzakouchaki
Volume 10, Issue 2 , August 2016, , Pages 113-121
Abstract
Nowadays, the use of dental implants in people with osteoporosis is increasing. The consequences of osteoporosis can be important to the success of osteosynthesis devices, prosthetics and dental implants. Using bisphosphonates, which with impressing bone remodeling and decreasing bone catabolic activity ...
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Nowadays, the use of dental implants in people with osteoporosis is increasing. The consequences of osteoporosis can be important to the success of osteosynthesis devices, prosthetics and dental implants. Using bisphosphonates, which with impressing bone remodeling and decreasing bone catabolic activity lead to increase bone formation can be used as a solution to increase bone density in patients with osteoporosis, which normally osteoporosis is considered as a risk to the acceptance of dental implants by alveolar bone. This study examines the effect of different concentrations of bisphosphonates on bone remodeling. By improving bone remodeling model and taking into account the drug concentration effect on bone resorption, drug effect will be considered. For this purpose, 5, 10 and 20 mg of alendronate per implant and control sample are simulated for a period of 360 days. By comparing the results with control sample, with increasing the drug dose, decrease in bone stress, increase in bone density and thus increase in young's modulus was observed.
Targeted Drug Delivery / Smart Drug Delivery / Drug Targeting
Seyed Ali Naghi Ahmadi; Tahere Fanaei Sheykhol-Eslami; Mehri Mehrjoo; Morteza Maleki
Volume 7, Issue 4 , June 2013, , Pages 351-360
Abstract
A secure self-biased remote controller for a drug delivery system, working at 956 MHz, is designed using piezoelectric substrate containing an implantable micropump. For this purpose, the effect of Lithium Niobate substrate on the actuation voltage, signal to noise ratio, insertion loss, bandwidth, and ...
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A secure self-biased remote controller for a drug delivery system, working at 956 MHz, is designed using piezoelectric substrate containing an implantable micropump. For this purpose, the effect of Lithium Niobate substrate on the actuation voltage, signal to noise ratio, insertion loss, bandwidth, and real and imaginary part of the admittance are investigated. The results of analytical calculation and numerical simulation show that the actuation voltage of the Lithium Niobate substrate is about 5.8 V, and the calculated bandwidth is 160 MHz with the signal to noise ratio of 26.52 dB. The security for actuation of the device is assured with Barker code. The insertion loss is equal to 2.1 dB which is adequate for maximum power transfer. Numerical simulation indicates that the generated voltage could create a displacement about 9.3353 nm in the conductive diaphragm, which is enough to ascertain the correct drug delivery by the micropomp. According to the analytical calculations and numerical simulations, the performance of the designed controller is qualified to correctly stimulate the drug delivery device.
