Biomechanics / Biomechanical Engineering
Hadi Nickbakht; Seyyed Yousef Ahmadi Brooghani; Vahid Arbabi
Volume 16, Issue 2 , September 2022, , Pages 159-166
Abstract
In a varus knee, the load balance on two sides of the knee joint is disturbed and the stress applied to the medial side of the joint will be greater than that of a healthy knee. Such a case is often progressive and gradually leads to wear and pain. In this study, the finite element model for two 3D samples ...
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In a varus knee, the load balance on two sides of the knee joint is disturbed and the stress applied to the medial side of the joint will be greater than that of a healthy knee. Such a case is often progressive and gradually leads to wear and pain. In this study, the finite element model for two 3D samples of healthy knee joint and varus knee in standing position was generated from MRI images and after loading and solving the problem, the stress distribution status in menisci and cartilage is obtained for both modes. The obtained results show the difference in maximum stresses and the difference in the shape of stress distribution areas. The results also show that the maximum values of von Mises stress and also the contact pressure in the inner area of the knee for the varus knee are much higher values compared to a healthy knee. In the standing position, the maximum contact pressure in the inner area of the joint, under a 400 N load applied to the upper end of the femoral head, was obtained 4.527 and 7.821 MPa for a healthy knee and varus, respectively. For maximum values of von Mises stress, 2.821 and 6.501 MPa was obtained respectively. Due to the results and differences in stresses, the need for surgery to balance the stresses and loads on two sides of the knee is essential for a patient with varus knees. The amount of correction can be determined in addition to examining the joint geometry by examining the differences in stresses on both sides of the joint in a more accurate way.
Cell Biomechanics / Cell Mechanics / Mechanobiology
Seyed Abed Hosseini; Mohammad Ali Khalilzadeh; Seyed Mehran Homam
Volume 4, Issue 1 , June 2010, , Pages 23-31
Abstract
Various stressful stimuli have different effects on health, decision making, creativity, learning and memory. Understanding human mental states such as stress can prevent its long-term side effects on the body and mind. This study deals with the responses of the neural and hormonal systems to stress ...
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Various stressful stimuli have different effects on health, decision making, creativity, learning and memory. Understanding human mental states such as stress can prevent its long-term side effects on the body and mind. This study deals with the responses of the neural and hormonal systems to stress using the brain cognitive map in this state and simulates the behavior of the CA1 cell calcium channels with electrophysiological equations in the NEURON software. During stress, the glucocorticoids hormones secreted by the adrenal gland cortex reach the hippocampus through blood flow and by activating glucocorticoids receptors, influence the calcium channels dynamics, especially the L-type and increase calcium entry into CA1 cells. This behavior, testify to the reduction of the calcium removal rate in the cells which leads to exponential decrease in cells firing rate and number of spikes and an increase in the sAHP current range. L-type calcium currents in hippocampus region are effective mechanisms during stress. Comparing the research results in two situations, the cell under control and the cell under stress, shows that the model is consistent with some basic observations of stress.
