Biological Computer Modeling / Biological Computer Simulation
Hosein Ghasemi; Mohammad Saeid Saeidi; Bahar Firoozabadi
Volume 7, Issue 3 , June 2013, , Pages 255-264
Abstract
Knowledge regarding particle deposition processes in the pulmonary system is important in aerosol therapy and inhalation toxicology applications. The present work describes a computational model of human lung airway consisting of the three-generation pathway from the trachea down to segmental bronchi. ...
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Knowledge regarding particle deposition processes in the pulmonary system is important in aerosol therapy and inhalation toxicology applications. The present work describes a computational model of human lung airway consisting of the three-generation pathway from the trachea down to segmental bronchi. In order to more appropriately model human air passage, an asymmetric geometry (i.e. three generation airway) is extracted from the 1th to 3th branches of the Hoursfield model and on dealing with the complexities of simulations (e.g. computation time) structured mesh is developed which also leads to more accurate computations. The fully three-dimensional incompressible laminar Navier– Stokes equations and continuity equation have been solved using CFD home code on generated mesh. Computations are carried out in the Reynolds number range of 800–1800, corresponding to mouthair breathing rates ranging from 0.18 to 0.41 l/s, representative. The study leads to establishing relations for overall particle deposition efficiency in the second generation of bronchial tree as a function of two dimensionless groups of Reynolds and Stocks numbers. Furthermore, interpretation of correlations are enlightened the fact of that in the initial generations of bronchial trees, consideration of asymmetric geometry has a significant influence on the particle deposition pattern. The results of the paper are valuable in aerosol therapy and inhalation toxicology.
Fluid-Structure Interaction in Biological Media / FSI
Hamed Avari; Farzan Ghalichi; Majid Ahmadlouy Darab
Volume 2, Issue 1 , June 2008, , Pages 39-46
Abstract
Adjusting the rhythm of breath is one of the important parameters that a successful athlete must consider. In this paper, the relationship between man's activity and respiration rhythm is studied. A numerical simulation is carried out on a 2D axi-symmetric model using computational fluid dynamics (CFD) ...
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Adjusting the rhythm of breath is one of the important parameters that a successful athlete must consider. In this paper, the relationship between man's activity and respiration rhythm is studied. A numerical simulation is carried out on a 2D axi-symmetric model using computational fluid dynamics (CFD) method. The model considers the oxygen uptake in the pulmonary capillaries in alveolar microcirculation system. The geometry consists of three main parts: a stationary capillary membrane, a moving plasma region and four semi-circular-shaped RBCs. Results show an inverse relationship between saturation time of RBCs and respiration rhythm. Using an inversion factor, a relationship is presented to assess the proper respiration rhythm for different exercise states.
