Computational Neuroscience
Maryam Moghadam,; Farzad Towhidkhah; Golnaz Baghdadi
Volume 15, Issue 2 , August 2021, , Pages 111-125
Abstract
In cognition physiology and neuroscience, spatial memory is responsible for the maintenance and recall of information related to environmental details, orientation, and spatial navigation. The brain’s cognitive functions including navigation are executed through correlated and sequential activities ...
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In cognition physiology and neuroscience, spatial memory is responsible for the maintenance and recall of information related to environmental details, orientation, and spatial navigation. The brain’s cognitive functions including navigation are executed through correlated and sequential activities of different regions. According to previous research, navigation is largely related to the activities of the Hippocampus (HPC) and the Medial Temporal Lobe (MTL), and retrieval of spatial memories from these regions is controlled by the frontal region and specifically medial prefrontal cortex (mPFC). In this paper we attempt to provide a navigation cognitive model based on computational concepts focusing on bidirectional interaction between HPC and mPFC. This model is provided considering 1. The lack of a comprehensive cognitive model of navigation on a previously learned path and ambiguities regarding the information transferring between the regions, and 2. Disagreement between available models and the currently known actual information flow occurring within the brain. The model is inclusive of the active brain regions engaged in navigation using the cognitive map. Furthermore, we propose a computational model based on van-der-pol neuron pools and controlling rule-base, which is naturally related to the actual brain activity through the synchrony mechanism for information transfer and the mPFC rule-based control of the medial temporal lobe. Finally, by analyzing and presenting evidence, we have shown that the model can be beneficial and practical for describing cognitive and functional disorders in navigation, also for design and prediction of the outcomes of therapeutic and rehabilitation protocols in diseases related to spatial navigation, such as the Alzheimer’s disease.
Cell Biomechanics / Cell Mechanics / Mechanobiology
Seyed Abed Hosseini; Mohammad Ali Khalilzadeh; Seyed Mehran Homam
Volume 4, Issue 1 , June 2010, , Pages 23-31
Abstract
Various stressful stimuli have different effects on health, decision making, creativity, learning and memory. Understanding human mental states such as stress can prevent its long-term side effects on the body and mind. This study deals with the responses of the neural and hormonal systems to stress ...
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Various stressful stimuli have different effects on health, decision making, creativity, learning and memory. Understanding human mental states such as stress can prevent its long-term side effects on the body and mind. This study deals with the responses of the neural and hormonal systems to stress using the brain cognitive map in this state and simulates the behavior of the CA1 cell calcium channels with electrophysiological equations in the NEURON software. During stress, the glucocorticoids hormones secreted by the adrenal gland cortex reach the hippocampus through blood flow and by activating glucocorticoids receptors, influence the calcium channels dynamics, especially the L-type and increase calcium entry into CA1 cells. This behavior, testify to the reduction of the calcium removal rate in the cells which leads to exponential decrease in cells firing rate and number of spikes and an increase in the sAHP current range. L-type calcium currents in hippocampus region are effective mechanisms during stress. Comparing the research results in two situations, the cell under control and the cell under stress, shows that the model is consistent with some basic observations of stress.
