Cell Biomechanics / Cell Mechanics / Mechanobiology
Seyed Abed Hosseini; Mohammad Ali Khalilzadeh; Seyed Mehran Homam
Volume 4, Issue 1 , June 2010, , Pages 23-31
Abstract
Various stressful stimuli have different effects on health, decision making, creativity, learning and memory. Understanding human mental states such as stress can prevent its long-term side effects on the body and mind. This study deals with the responses of the neural and hormonal systems to stress ...
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Various stressful stimuli have different effects on health, decision making, creativity, learning and memory. Understanding human mental states such as stress can prevent its long-term side effects on the body and mind. This study deals with the responses of the neural and hormonal systems to stress using the brain cognitive map in this state and simulates the behavior of the CA1 cell calcium channels with electrophysiological equations in the NEURON software. During stress, the glucocorticoids hormones secreted by the adrenal gland cortex reach the hippocampus through blood flow and by activating glucocorticoids receptors, influence the calcium channels dynamics, especially the L-type and increase calcium entry into CA1 cells. This behavior, testify to the reduction of the calcium removal rate in the cells which leads to exponential decrease in cells firing rate and number of spikes and an increase in the sAHP current range. L-type calcium currents in hippocampus region are effective mechanisms during stress. Comparing the research results in two situations, the cell under control and the cell under stress, shows that the model is consistent with some basic observations of stress.
