Cell Biomechanics / Cell Mechanics / Mechanobiology
Hamid Khaloozadeh; Pedram Yazdanbakhsh; Fateme Homaei Shandiz
Volume 1, Issue 4 , June 2007, , Pages 319-334
Abstract
The optimal doses of Doxorubicin and Cyclophosphamide (AC) regimen in pre-operation Neoadjuvant chemotherapy for the patients suffering from stage III breast cancer were investigated. The major benefit of Neoadjuvant chemotherapy is that it can shrink large cancers so that they are small enough to be ...
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The optimal doses of Doxorubicin and Cyclophosphamide (AC) regimen in pre-operation Neoadjuvant chemotherapy for the patients suffering from stage III breast cancer were investigated. The major benefit of Neoadjuvant chemotherapy is that it can shrink large cancers so that they are small enough to be removed by lumpectomy instead of mastectomy. The optimal regimen designed in this paper was based on the special conditions that every patient had been treated by her/his own physician and the resistance of tumor cells. With respect to these regimen that can achieve non equivalent doses of drug in treatment times for neoadjuvant chemotherapy. The purpose of treating the patients with cancer in neoadjuvant chemotherapy could be either destroying the cancer cells or preserving the normal cell populations in the best way, or different cases between these two situations. In this article, by solving a cost function involved with the dynamics of both cancer cells and normal cells - using the appropriate weighting coefficients suggested by the treating physician- the optimal doses of AC drugs for the patients suffering from breast cancer at stage III were computed by the proposed optimal controller.
Targeted Drug Delivery / Smart Drug Delivery / Drug Targeting
Fariba Ourang; Mohammad Rafienia
Volume -1, Issue 2 , June 2005, , Pages 173-179
Abstract
Polyurethane micro spheres have been synthesized by solvent evaporation technique with castor oil, Polycaprolacton (PCL), Hexamethylen diisocyanate (HMDI) and Ethyl diamine (ED) as carriers for controlled drug delivery systems. Release behavior of micro spheres has been investigated using Bromocresol ...
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Polyurethane micro spheres have been synthesized by solvent evaporation technique with castor oil, Polycaprolacton (PCL), Hexamethylen diisocyanate (HMDI) and Ethyl diamine (ED) as carriers for controlled drug delivery systems. Release behavior of micro spheres has been investigated using Bromocresol purple die. Fourier transmission infrared (FTIR), Scanning Electron Microscope (SEM), Optical microscope, dissolution instrument and UV spectrophotometer were used to investigate the polymerization process, surface morphology, particle size, rate of release and calibration curve respectively. Results showed that urethane bonds were formed at 3300-3400cm-1 and 1650-1700 cm-1. SEM micrographs showed surface irregularities as a result of solvent evaporation. Particle sizes were higher for castor oil/HMDI rather than PCL/HMDI microbe ads and in both cases, particle size and Bromocresol purple die release increased with rising NCO/OH ratio.
