نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد،گروه زیست‌شناسی، دانشکده علوم، دانشگاه آزاد اسلامی واحد دامغان

2 دانشیار، گروه زیست‌شناسی، دانشکده علوم، دانشگاه آزاد اسلامی واحد دامغان

3 دانشیار، گروه بهداشت حرفه‌ای، دانشکده بهداشت، دانشگاه علوم پزشکی قزوین

10.22041/ijbme.2012.13105

چکیده

مواجهه مزمن با میدان‌های مغناطیسی می‌تواند آثار نامطلوبی بر حافظه و یادگیری داشته باشد. این مطالعه با هدف بررسی اثر حفاظتی عصاره زعفران بر اختلالات تثبیت حافظه در رت‌های در معرض تابش میدان مغناطیسی انجام شد. 120 موش صحرایی نر از نژاد ویستار در 12 گروه ده‌تایی به مدت 5 روز، هر روز به مدت 1، 3 و 5 ساعت در معرض تابش میدان مغناطیسی با شدت 5/2 تسلا قرار گرفتند و آثار حفاظتی عصاره زعفران با دوزهای 125 ،200 ، 300  میلی‌گرم برکیلوگرم در سطح معنی‌دار (05/0p) به روش یادگیری احترازی غیر فعال در دستگاه شاتل باکس در مقایسه با گروه کنترل بررسی شد. مواجهه یک ساعتی موش‌ها با میدان مغناطیسی تأثیر معنی‌داری بر تثبیت حافظه نداشت. افزایش زمان مواجهه به 3 و5 ساعت در مقایسه با گروه کنترل سبب اختلال درتثبیت حافظه شد(05/0P<). تجویز درون صفاقی عصاره زعفران در دوز 300  میلی‌گرم عصاره بر کیلوگرم تأثیر معنی‌داری در بهبود تثبیت حافظه در مقایسه با گروه کنترل داشت. تابش میدان مغناطیسی 5/2 میلی تسلا و50 هرتز سبب اختلال در تثبیت حافظه شد. عصاره آبی زعفران با دوز 300  میلی‌گرم بر کیلوگرم ممکن است دارای آثار حفاظتی و بهبود دهنده اختلالات تثبیت حافظه شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Protective effects of saffron extract against consolidation Impairment memory induced by magnetic field in rats

نویسندگان [English]

  • Samane Sedighi 1
  • Keyvan Keramati 2
  • Ali Safari-Varyani 3
  • Ahmad Nikpey 3

1 M.Sc., Department of Biology, Islamic Azad University of Damghan

2 Associate professor, Department of Biology, Islamic Azad University of Damghan

3 Associate professor, Department of Occupational Health, Qazvin University of Medical Sciences

چکیده [English]

Exposure to magnetic fields can effect on the learning and memory. The protective effect of saffron extract on memory consolidation disorders in rats exposed to magnetic fields was investigated. 120 male Wistar rats in 12 groups exposed to magnetic field For 5 days with intensity 2.5 tesla for 1, 3 and 5 hour and protective effects of saffron extract with doses of 125 mg, 200 mg and 300 mg (P ≤0.05) compared to the control group by passive avoidance learning method in shuttle box. One hour exposure with magnetic field had no effect on the rats’ memory consolidation (P ≤0.05). Increase exposure time to 3 and 5 hours had a memory consolidation Impairment compared to the control group (P ≤0.05). Administered rats with 300 mg Inter peritoneal saffron extract improved memory consolidation (P ≤0.05) compared to the control group. Exposure to magnetic fields 2.5 mT, 50 Hz impair memory consolidation. Saffron aqueous extract at a dose of 300 mg per kg may have a protective effect and be improvement consolidation impairments.

کلیدواژه‌ها [English]

  • Magnetic fields
  • Consolidation memory
  • Aqueous extract of saffron
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