نوع مقاله: مقاله کامل پژوهشی

نویسندگان

1 استادیار، گروه برق، دانشکده مهندسی، دانشگاه فردوسی مشهد

2 دانشیار، گروه فیزیک پزشکی، مرکز تحقیقات فیزیک پزشکی، پژوهشکده بوعلی، دانشگاه علوم پزشکی مشهد

3 دانشیار، گروه مهندسی پزشکی، دانشگاه تربیت مدرس

10.22041/ijbme.2010.13297

چکیده

امروزه ایده درمان فوتوداینامیک (PDT)، یکی از پایه‌های اساسی روش‌های نوین درمان سرطان به‌شمار می‌آید. موضوع حائز اهمیت در کاربرد این روش درمانی، دوزیمتری بهینه است. در حالت بهینه، بهتر است دوزیمتری PDTبر اساس تخمین دوز تجمع یافته اکسیژن یگانه درون بافت و مقایسه آن با مقدار آستانه باشد تا از نتیجه درمان اطمینان حاصل شود. مدلسازی فرایند درمان مناسب‌ترین روش برای تخمین دوز تجمع یافته اکسیژن یگانه درون بافت است. بنابراین لازم است اطلاعات کافی در مورد غلظت دارو درون بافت هدف، میزان نور جذب شده به‌وسیله دارو، میزان اکسیژن درون بافت هدف و برهمکنش بین آنها (منجر به تولید اکسیژن یگانه) به‌دست آید. با توجه به اهمیت تعیین مقدار دارو درون بافت هدف و توجه به این امر که به دلیل فتوبلیچینگ، کاهش قابل ملاحظه‌ای در غلظت دارو ضمن درمان رخ می‌دهد، در این تحقیق به مدلسازی و شبیه‌سازی اثر فتوبلیچینگ پرداخته شده است. شبیه‌سازی در فضای MATLABانجام شده است. مقایسه نتایج شبیه‌سازی با نتایج تجربی نشان می‌دهد که در حالت اعمال توزیع‌پذیری غیریکنواخت دارو، شبیه‌سازی در فاز اولیه افت سریع غلظت دارو، به‌خوبی از نتایج تجربی پیروی می‌کند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Modeling and Simulation of PpIX Photobleaching Mechanism to Determine Its Concentration within the Target Tissue in Photodynamic Therapy

نویسندگان [English]

  • Nadia Naghavi 1
  • Amene Sazgarnia 2
  • Mohammad Hossein Miranbaygi 3

1 Assistant Professor, Department of Electrical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad

2 Associate Professor, Medical Physics Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences

3 Associate Professor, Department of Biomedical Engineering, Faculty of Electrical & Computer Engineering, Tarbiat Modares University

چکیده [English]

Today, the idea of photodynamic therapy (PDT) is considered as one of the fundamental basis of the new cancer treatment methods. One of the important issues in the application of this therapy is choosing the optimal dosimetry method. At best, PDT dosimetry should be done based on estimation of the accumulated singlet oxygen dose within the target tissue and comparison with the threshold value to ensure the efficacy of the treatment. In order to estimate the accumulated singlet oxygen level within the tissue, the most appropriate method is modeling the process of treatment. In this context, it is necessary to obtain enough information about the drug concentration within the target tissue, the amount of light absorbed by the drug, the amount of oxygen into the tissue, and the interactions between them that produce singlet oxygen. In this study modeling and simulation of the photobleaching has been investigated, considering the importance of the level of drug concentration in the target tissue which would be decreased by photobleaching. Simulation was done with Matlab software. A Comparison of simulation results with those of experimental methods showed that in the state of non-uniform drug distribution, simulation follows experimental results at the initial phase of rapid decline of drug concentration.

کلیدواژه‌ها [English]

  • Modeling
  • Photodynamic therapy
  • Photobleaching
  • Dosimetry
  • Protoporphyrin IX

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