Iranian Society for Biomedical EngineeringIranian Journal of Biomedical Engineering5869-20081220070823Determination Of Elastic Modulus Of Artery Wall By Modeling Of Artery Wall And Blood FlowDetermination Of Elastic Modulus Of Artery Wall By Modeling Of Artery Wall And Blood Flow951041348910.22041/ijbme.2007.13489FAMehdi MaerefatAssociate professor, Mechanics Department, Engineering School, Tarbiat Modares UniversityAsghar Khoushkar ShalmaniMS Mechanical Engineer, Engineering School, Tarbiat Modares UniversityManije Mokhtari DizajiAssociate professor, Medical Physics Department, Medical School, Tarbiat Modares UniversityJournal Article20150629Modeling of blood flow and arterial wall in large arteries such as carotid artery, using ultrasonic measurements, allows non-invasive evaluation of clinically interesting homodynamic variables. In this study, a nonlinear mathematical model for the pulsatile arterial flow is proposed using the approximation of “local flow” theory. The blood velocity profile, the pressure gradient and the elastic modulus can be calculated using the model by measuring instantaneous radius and center-line blood velocity. An original mathematical model of pressure gradient in a tapered and elastic tube, using center-line blood velocity, is presented. A Newtonian incompressible Navier-Stokes solver coupled with elastic or visco-elastic arterial wall model is developed to solve the equations of model. The results of modeling and simulation indicate that the approach can estimate the elastic modulus of arterial wall from ultrasonic data. There is a good agreement between the computed arterial wall elasticity and the measured one. The method presented is relatively simple to implement clinically and can be taken as a new diagnostic tool for detecting local vascular change.Modeling of blood flow and arterial wall in large arteries such as carotid artery, using ultrasonic measurements, allows non-invasive evaluation of clinically interesting homodynamic variables. In this study, a nonlinear mathematical model for the pulsatile arterial flow is proposed using the approximation of “local flow” theory. The blood velocity profile, the pressure gradient and the elastic modulus can be calculated using the model by measuring instantaneous radius and center-line blood velocity. An original mathematical model of pressure gradient in a tapered and elastic tube, using center-line blood velocity, is presented. A Newtonian incompressible Navier-Stokes solver coupled with elastic or visco-elastic arterial wall model is developed to solve the equations of model. The results of modeling and simulation indicate that the approach can estimate the elastic modulus of arterial wall from ultrasonic data. There is a good agreement between the computed arterial wall elasticity and the measured one. The method presented is relatively simple to implement clinically and can be taken as a new diagnostic tool for detecting local vascular change.https://www.ijbme.org/article_13489_2b9b93b9daf078dbcc86e6c44d57320b.pdf