Mathematical Modeling and Simulation in order to Evaluation of the Nanoparticle Size in the Magnetic Drug Targeting System

Valizadeh, Gelare; Fatemi, Fateme; Shahabadi, Mahmoud; Oghabian, Mohammad Ali; Pouladian, Majid

doi:10.22041/ijbme.2014.13027

Mathematical Modeling and Simulation in order to Evaluation of the Nanoparticle Size in the Magnetic Drug Targeting System

Document Type : Full Research Paper

Authors

Gelare Valizadeh ¹

Fateme Fatemi ¹

Mahmoud Shahabadi ²

Mohammad Ali Oghabian ³

Majid Pouladian ⁴

¹ Research Center for Science and Technology in Medicine, Faculty of Engineering, science and research branch, Islamic Azad University, Tehran, Iran

² School of Electrical and Computer Engineering, College of Engineering, Tehran University, Tehran, Iran

³ Research Center for Science and Technology in Medicine, Faculty of Medical Physics, Tehran University, Tehran, Iran

⁴ Faculty of Engineering, science and research branch, Islamic Azad University, Tehran, Iran

https://doi.org/10.22041/ijbme.2014.13027

Abstract

MTDDS is an innovative treatment modality to completely tumor remission with no negative side effect. In this method functionalize magnetic nanoparticles are designed as the drug carrier to get the specific target in the body. Anticancer agents are bounded to magnetite nanoparticles with biocompatible starch coating suspended in the fluid. Now if they are injected intra-arterially near the target volume, they would be trapped at the target region via a local applied magnetic field with the high gradient near the target site. In this paper we have evaluated some nanoparticle trajectories with different size in order to evaluate the effect of the size on the efficiency of the magnetic drug targeting system.

Keywords

Magnetic drug delivery

Nanoparticle

Iron oxide

COMSOL

Particle

Subjects

Biological Computer Modeling / Biological Computer Simulation

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