Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Investigation of Channel Aspect Ratio and PEO Polymer Concentration Effect on Separation of Bio Particle in 100 nm up to 1000 nm using Viscoelastic Fluid in Micro Channel

Document Type : Full Research Paper

Authors

Leila Karamimonfared 1
Shahram Talebi 2
Mehdi Mohammadi 3

1 Ph.D. Student, Department of Mechanical Engineering, Yazd University, Yazd, Iran

2 Associate Professor, Department of Mechanical Engineering, Yazd University, Yazd, Iran

3 Associate Professor, Department of Mechanical Engineering, University of Calgary, Calgary, Canada

https://doi.org/10.22041/ijbme.2023.2003001.1844
Abstract
Early recognition of common diseases, including cancer, plays an essential role in preventing the progression of the disease. Among the various methods that have been invented for blood monitoring in recent years, the methods based on the use of micro-scale flow have received special attention. Isolation of biological nanoparticles is widely used in diagnosis, treatment and care in the field of medicine. Recent research on nano-sized extracellular carriers is of interest in the field of medicine. Biological nanoparticles such as viruses, DNA, proteins and exosomes contain significant information that can help diagnose and treat diseases such as cancer. One of the practical and effective methods for separating nanoparticles is the use of viscoelastic fluid, which does not have the complications of other methods. Unlike microparticles, the number of studies in the field of bio nanoparticles is low. Since previous research in the field of nanoparticle separation lacks comprehensive numerical information about the effect of aspect ratio and polymer concentration, in this article, the viscoelastic fluid flow along with particle physics has been numerically simulated with COMSOL Multiphysics software. The effective parameters including aspect ratio 1, 1.5 and 2 and polymer concentration 0.05%, 0.15% and 0.25% have been investigated in the separation of 1000 up to 100 nm particles. Separation of 300 and 500 nm particles at a concentration of 0.05% and the channel with an aspect ratio 1 and 1.5 has been obtained from the other particles. It is possible to separate the particle 100 nm as exosome particle from the other particles at an aspect ratio 2 and a polymer concentration of 0.05% as the best choice.

Keywords

Separation
Bio Particle
Nanoparticle
Viscoelastic Fluid
Microfluidic

Subjects

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Iranian Journal of Biomedical Engineering (IJBME)
Volume 17, Issue 1
Spring 2023
Pages 46-58

  • Receive Date 02 June 2023
  • Revise Date 26 September 2023
  • Accept Date 04 October 2023

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