The Assessment of Core and Peritumoral Areas of Glioma Brain Tumors Using Diffusion and Perfusion Imaging

Azimi, Leila; Riahi Alam, Nader; Firuozniya, Kavoos; Saligheh Rad, Hamid Reza; Miri, Mojtaba; Pakravan, Manizheh; Shahmohammadi, Anamollah

doi:10.22041/ijbme.2014.13026

The Assessment of Core and Peritumoral Areas of Glioma Brain Tumors Using Diffusion and Perfusion Imaging

Document Type : Full Research Paper

Authors

Leila Azimi ¹

Nader Riahi Alam ²

Kavoos Firuozniya ³

Hamid Reza Saligheh Rad ⁴

Mojtaba Miri ⁵

Manizheh Pakravan ⁶

Anamollah Shahmohammadi ⁷

¹ M.Sc Student, Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences, Tehran

² Professor, Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences, Tehran

³ Assistant professor, Imaging Research Department Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran

⁴ Assistant professor, Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences, Tehran

⁵ Assistant professor, Neurosurgery Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran

⁶ B.Sc, Imaging Research Department Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran

⁷ B.Sc, Radiology Department, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin

https://doi.org/10.22041/ijbme.2014.13026

Abstract

Gliomas are the most common primary neoplasm of the brain, varying histologically from low grade to high-grade. Perfusion-weighted MRI techniques have permitted the creation of cerebral blood volume (CBV) value, leading to the qualitative and quantitative assessment of tumor vascularity. This research aimed at assessing the rCBV and the ADC values in core and peritumoral areas glioma brain tumors and determining of significance rCBV of values i Alpha I In evaluating brain tumor. Ten patients with non-enhancing supratentorial gliomas were evaluated by diffusion weighted imaging (DWI) and standard dynamic susceptibility contrast-enhanced gradient echo during first pass of a bolus injection of contrast material before surgical resection. Six low-grade gliomas (WHO Grade II) and 4 high-grade gliomas (III, IV) were evaluated. Alpha Both the apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) values were calculated by a standard program on the solid portion of the tumor in the peritumoural area as well as contra lateral white matter. In perfusion, mean rCBVmax in high-grade and low-grade tumors were obtained (3.47±0.92), (2.37±0.49)-(1.66±0.68), (1.15±0.39) for core and peritumoral regions, respectively. In diffusion method, mean ADC in high-grade and low grade tumors were (0.53±0.07), (0.91±0.18)-(1.24±0.27), (1.007±0.33) for core and peritumoral regions, respectively. It was concluded that the values rCBVs are important in determining the grade of tumor and we propose that perfusion weighted imaging be done for all patients before surgery.

Keywords

Glioma

Diffusion Weighted Imaging

Perfusion Weighted Imaging

apparent diffusion coefficient

Subjects

Biomedical Image Processing / Medical Image Processing

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