Modeling the Effects of Biomechanical Factors on the Deformability of Metastatic Cancer Cells

Navidbakhsh, Mehdi; Jafarnejad, Milade

doi:10.22041/ijbme.2010.13342

Modeling the Effects of Biomechanical Factors on the Deformability of Metastatic Cancer Cells

Document Type : Full Research Paper

Authors

Mehdi Navidbakhsh ¹

Milade Jafarnejad ²

¹ Associate Professor, School of Mechanical Engineering, Iran University of Science and Technology

² M.Sc Graduated, BioMedical Engineering School, Research and Sciences Branch, Islamic Azad University

https://doi.org/10.22041/ijbme.2010.13342

Abstract

The cancer changes the cytoskeleton of the cells .This change has some effects on the cell mechanobiology and will lead to some changes in the deformability of the cells. The moving ability of the cancer cells would be more than healthy cells. Thus, they can migrate through the tissue in human body. In this survey, a valid FEM of a cancer cell is presented. Then the effects of various factors such as membrane thickness, elasticity, strain, and frequency response are studied during a process of being converted from normal cells into cancerous malignant cells. Besides, the initial mathematical models are provided. The results clarify that an increase in membrane elasticity, strain, and frequency would lead to increase in the reaction force. However, an increase in the membrane thickness decreases the reaction force.

Keywords

Cell skeleton

Finite element

Cancer cell

Deformability

Viscoelasticity

Subjects

[1] Suresh. S., Biomechanics and biophysics of cancer cells. Acta Biomaterialia, 2007; 3: 413–438.

[2] Suresh S., Spatz J., Mills J.P., Micoulet A., Dao Lim C.T., Beil M., Seufferlein T., Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. Acta Biomaterialia, 2005; 1: 15–30.

[3] Janmey P.A., Euteneuer U., Traub P., Schliwa M., Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J Cell Biol 1991; 113: 155–60.

[4] Martin R.B., Burr D., Sharkey N., Skeletal tissue mechanics. NewYork: Springer-Verlag; 1998: 16-26.

[5] Vaziri A., Gopinath A., Deshpande V.S., Continuumbased computational models for cell and nuclear mechanics. The Journal of Mechanics of Materials and Structures, 2007; 2 (6): 21-30.

[6] Hochmuth R.M., Micropipette aspiration of living cells .J Biomech, 2000; 33: 15-22.