Document Type : Full Research Paper


1 Bioceramics Lab, Department of Biomedical Engineering, AmirKabir University of Technology

2 School of Mechanical Engineering, Iran University of Science & Technology



The conditions for synthesis of amorphous calcium phosphates (ACPs) according to the crystallization principles were described. By selecting reaction parameters correctly (low temperature, high pH, immediate removing of water and using solutions containing calcium cations and phosphate anions at low concentrations), full ACPs can be reproducibly synthesized. The X-ray diffraction patterns of synthesized amorphous specimens were showed a characteristic broad peak. The Ca/P ratio of the resulting precipitates was weakly dependent on the initial Ca/P ratio. Solubility of synthesized specimens in simulated osteoclastic activity conditions was showed that the rate of dissolution would be decreased with increasing crystallinity level. The synthesized amorphous calcium phosphates showed the highest dissolution rate in the simulated solution, and can be a suitable candidate for using in the field of hard tissue engineering applications.


Main Subjects

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