Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Synthesis Of Amorphous Calcium Phosphate And Its Solubility Behavior In Simulated Osteoclastic Activity Conditions

Document Type : Full Research Paper

Authors

Abdorreza Sheikh Mehdi Mesgar 1
Zahra Mohammadi 2

1 Bioceramics Lab, Department of Biomedical Engineering, AmirKabir University of Technology

2 School of Mechanical Engineering, Iran University of Science & Technology

10.22041/ijbme.2004.13515
Abstract
The conditions for synthesis of amorphous calcium phosphates (ACPs) according to the crystallization principles were described. By selecting reaction parameters correctly (low temperature, high pH, immediate removing of water and using solutions containing calcium cations and phosphate anions at low concentrations), full ACPs can be reproducibly synthesized. The X-ray diffraction patterns of synthesized amorphous specimens were showed a characteristic broad peak. The Ca/P ratio of the resulting precipitates was weakly dependent on the initial Ca/P ratio. Solubility of synthesized specimens in simulated osteoclastic activity conditions was showed that the rate of dissolution would be decreased with increasing crystallinity level. The synthesized amorphous calcium phosphates showed the highest dissolution rate in the simulated solution, and can be a suitable candidate for using in the field of hard tissue engineering applications.

Keywords

Amorphous Calcium Phosphates
Calcium phosphate cement
Hard Tissue Engineering
Solubility
Osteoclastic Activity
Synthesis Of Amorphous Materials

Subjects

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  • Receive Date 30 June 2015

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