Effect Of Chemical Composition On Release Behavior And Morphology Of Polyurethane Microspheres Prepared By Solvent Evaporation Method

Ourang, Fariba; Rafienia, Mohammad

doi:10.22041/ijbme.2005.13528

Authors

Biomaterials Group, Department of Biomedical Engineering, Amir Kabir University of Technology

10.22041/ijbme.2005.13528

Abstract

Polyurethane micro spheres have been synthesized by solvent evaporation technique with castor oil, Polycaprolacton (PCL), Hexamethylen diisocyanate (HMDI) and Ethyl diamine (ED) as carriers for controlled drug delivery systems. Release behavior of micro spheres has been investigated using Bromocresol purple die. Fourier transmission infrared (FTIR), Scanning Electron Microscope (SEM), Optical microscope, dissolution instrument and UV spectrophotometer were used to investigate the polymerization process, surface morphology, particle size, rate of release and calibration curve respectively. Results showed that urethane bonds were formed at 3300-3400cm^-1 and 1650-1700 cm^-1. SEM micrographs showed surface irregularities as a result of solvent evaporation. Particle sizes were higher for castor oil/HMDI rather than PCL/HMDI microbe ads and in both cases, particle size and Bromocresol purple die release increased with rising NCO/OH ratio.

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Iranian Journal of Biomedical Engineering

Effect Of Chemical Composition On Release Behavior And Morphology Of Polyurethane Microspheres Prepared By Solvent Evaporation Method

References

References

Volume -1, Issue 2 - Serial Number 2
June 2005
Pages 173-179

Effect Of Chemical Composition On Release Behavior And Morphology Of Polyurethane Microspheres Prepared By Solvent Evaporation Method

References

References

Volume -1, Issue 2 - Serial Number 2June 2005Pages 173-179

Volume -1, Issue 2 - Serial Number 2
June 2005
Pages 173-179