Document Type : Full Research Paper


1 Ph.D Student, Mechanical Engineering Department, Tarbiat Modares University, Tehran, Iran

2 Associate Professor, Mechanical Engineering Department, Tarbiat Modares University, Tehran, Iran

3 Professor, Department of Physiology, School of Medical Sciences Tarbiat Modares Universityو Tehran, Iran



In this paper the simulation of pathological behavior in gait locomotion of central nervous system (CNS) diseases and effects of rehabilitation techniques are investigated. These simulations noticeably deepen the knowledge of researches in neurorehabilitation realm about the neuroscientific basis of CNS treatment after a neural disorder. However, only a limited number of these simulations have been proposed in the previous works that issued some aspects of CNS diseases. Due to this limitation, in this paper, a more efficient simulation has been done on pathological behavior of neural disorders with including the brain signal disruption in the models. To do this, combinations of neural reflexes and central pattern generator (CPG) has been incorporated in the neuromuscular system and examined on two different msculoskeletal system containing two leg-one segment and one leg-two segment systems. Then, the locomotion of hemiplegia and paraplegia patients are simulated by inserting a malfunction in the supraspinal signal coming into the CPG. Moreover, the effects of rehabilitation effects on paraplegia patients have been investigated and qualititatively compared to the experimental data.


Main Subjects

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