Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Numerical modeling of cerebral autoregulation in human common carotid artery

Document Type : Full Research Paper

Authors

Saeid Siri 1
Malikeh Nabaei 2
Nasser Fatouraee 3

1 M.Sc. Student, Biomechanic Department, Biomedical Engineering Faculty, AmirKabir University of Technology, Tehran, Iran.

2 Assistant Professor,Biomechanic Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran

3 Assosiate Professor, Biomechanic Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran

https://doi.org/10.22041/ijbme.2016.20436
Abstract
Every organ has its own metabolic and functional requirements and needs a variable amount of blood; hence, autoregulation is an important phenomenon. Shear stress induced autoregulation is defined as the innate ability of an organ to keep its hemodynamic conditions stable against changes in heart rate and perfusion pressure. For example, when heart rate changes arterial vessels undergo vasodilation or vasoconstriction in order to stabilize the hemodynamic forces and stresses with respect to the flow needed. The current study examines the local mechanisms employed in automatic control. Local regulatory mechanisms function independently of external control mechanisms, such as sympathetic nerves and endocrine hormones. Therefore, they can be considered isolated mechanisms. The application of boundary conditions in numerical modeling is of utmost importance, hence, using arterial tree modeling to achieve appropriate boundary conditions seems necessary. Thus, we have presented a zero-dimensional (lumped parameter) extensive model first. Then, we used this model to achieve boundary conditions for the common carotid artery. As one of the most important hemodynamic parameters, shear stress regulation will then be modeled in an axisymmetric model of this artery.

Keywords

Lumped parameter model
fluid-structure interaction
cerebral artery
Shear stress
arterial vasodilation and vasoconstriction

Subjects

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Iranian Journal of Biomedical Engineering (IJBME)
Volume 9, Issue 3
Autumn 2015
Pages 229-241

  • Receive Date 16 April 2016
  • Revise Date 18 June 2016
  • Accept Date 02 July 2016

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