Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

A Model for Time Constant of Ionic Channels in Neurons

Document Type : Full Research Paper

Authors

Seyed Hojat Sabzpoushan 1
Azadeh Ghajarjazy 2

1 Assistant Professor, Biomedical Engineering Department,School of Electrical Engineering,Iran University of Science & Technology,Tehran,Iran

2 PhD Candidate, Biomedical Engineering Department,School of Electrical Engineering,Iran University of Science & Technology,Tehran,Iran

https://doi.org/10.22041/ijbme.2016.22214
Abstract
Time constant is a physical concept that one may deduce the speed of response and reaction of a system from it. Experimental findings confirm the dependency of the speed of opening-closing of ionic channels to the membrane voltage. In this paper a model for time constant of membrane voltage in neurons has been presented. At first, the presented model has been established as a theorem and then the theorem has been proved. According to the presented theorem, one can simulate different morphology and time course of action potential (AP) in neurons by adjusting the model parameters. The validation of the presented theorem (model) has been shown by simulation examples of some kinds of neurons and cells APs. Regarding the generality of the presented theorem, our model not only can be applied in biomedical systems but also it may be used in any physical systems.

Keywords

Ion channel
Time constant
Modelling
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Iranian Journal of Biomedical Engineering (IJBME)
Volume 9, Issue 3
Autumn 2015
Pages 267-282

  • Receive Date 19 November 2015
  • Revise Date 12 January 2016
  • Accept Date 17 October 2016

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