Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Investigation of The Optimal Synthesis Conditions of Biocompatible Cerium Oxide Nanoparticles by Microfluidic Chip

Document Type : Full Research Paper

Authors

Mohadese Shahriaripour 1
Sasan Asiaei 2

1 M.Sc. Student, Biomedical Engineering Group, Mechanical Engineering Department, Iran University of Science and Technology, Tehran, Iran

2 Assistant Professor, Biomedical Engineering Group, Mechanical Engineering Department, Iran University of Science and Technology, Tehran, Iran

https://doi.org/10.22041/ijbme.2021.526771.1675
Abstract
Cerium oxide nanoparticles have many applications in medicine. Particle size, shape and concentration of nanoceria are very important for biological applications and biocompatibility. The synthesis method of cerium oxide nanoparticles has an important role in determining nanoceria shape, particle size and concentration. In this project, the effective parameters in determining the concentration, size and size distribution, crystallinity and production of maximum cerium oxide produced from the reactants were simulated and tested. Since in different method, particle size control has become an important challenge, microfluidic chips were used to control particle size. Among the existing methods for nanoparticle synthesis, co-precipitation method was chosen because of its simplicity, cheapness and short time method compared with other methods. Cerium nitrate and sodium hydroxide were used as raw materials to synthesize cerium oxide nanoparticles. Simulations were performed in Comsol and then the results were used for experimental tests, comparison and validation. The nanoparticles were characterized for size and size distribution using x-ray diffraction. The results of this study showed that the use of microfluidic chips is an effective method for controling nanoparticle size. Increasing concentration of sodium hydroxide can complete reaction and have maximum efficiency and decreasing the reactives velocity can reduce the size dispersion, increases the crystallinity and particle size. The yellow precipitate produced, according to Scherer equation, contains cerium oxide nanoparticles with particle size of 1.16±0.1 nm and 85% of crystallinity.

Keywords

Nanoparticles
Microfluidic Chip
Cerium Oxide
Ceria Nanoparticles
Co-Precipitation Method

Subjects

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Iranian Journal of Biomedical Engineering (IJBME)
Volume 15, Issue 1
Spring 2021
Pages 87-97

  • Receive Date 15 March 2021
  • Revise Date 02 May 2021
  • Accept Date 16 May 2021

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