Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Quantitative Analysis of Biomechanical Parameters of Bioinspirational Designed Medical Microneedles in Interaction with Skin using Finite Elements Method

Document Type : Full Research Paper

Authors

Yasaman Amiri, 1
Bahman Vahidi 2

1 M.Sc., Biomedical Engineering-Biomechanics, Faculty of New Sciences and Technologies (FNST), University of Tehran, Tehran, Iran

2 Associate Professor, Biomedical Engineering Department, Faculty of New Sciences and Technologies (FNST), University of Tehran, Tehran, Iran

https://doi.org/10.22041/ijbme.2021.141559.1652
Abstract
Microneedles are a type of micron-sized needle that is the third most widely used delivery system after oral and injectable drug delivery, used in a variety of fields including drug release and rejuvenation. Optimizing the geometry of microneedles to reduce pain and inflammation has been important in recent years. Due to the high cost of microneedle fabrication, numerical simulation of microneedle penetration into the skin can be useful to evaluate the microneedle strength as well as its effect on the skin during penetration. In this study, first a new simulation method in Abaqus software with explicit method using cohesive elements to investigate the penetration of microneedles in the skin of the human forearm was presented. The skin was considered as Ogden and bilayer hyperelastic models. The microneedle was considered as a rigid body and a constant velocity of 0.6 mm/s was applied to it .The microneedle with bulk with bio-inspired titles was examined and its important parameters such as height, sharpness and bulk angle were evaluated. Finally, some proposed models of microneedles with longitudinal grooves are presented to increase the concentration of stress on the skin and prevent friction. A comparison of the designed microneedle with the barbless microneedle shows that the barbed microneedle concentrates more than twice as much stress on the skin, but reduces the penetration force by as much as 15%, making it easier to penetrate the skin. The results show that the reduction longitudinal grooves increase the tension created in the skin by about 10%, but have little effect on the penetrating force on the skin.

Keywords

Abaqus
Bioinspiration
Microneedle
Cohesive Element
Finite Element Method

Subjects

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Iranian Journal of Biomedical Engineering (IJBME)
Volume 15, Issue 2
Summer 2021
Pages 99-110

  • Receive Date 15 December 2020
  • Revise Date 13 June 2021
  • Accept Date 25 August 2021

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