Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Numerical Analysis of 3D Model of Spinal Cord in Syringomyelia Disease Conditions Using Fluid-Solid Interface Technique

Document Type : Full Research Paper

Authors

Hoda Mastari Farahani 1
Nasser Fatouraee 2

1 M.Sc, Biomechanic Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran

2 Associate Professor, Biomechanic Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran

https://doi.org/10.22041/ijbme.2017.72939.1275
Abstract
Syrinx growth in Syringomyelia desease causes progressive neurological disorders. Thus, the examination of effective factors in syrinx development is so important for controlling this desease. One of clinical assumptions related to the reason of syrinx development, considers the propagation of pressure wave shock in subarachnoid-space fluid as the main reason for fluid motion in syrinx and syrinx development and increasing damage to spinal cord. Modeling and analysis have been performed to test the theory in this research using finite element method. So a 3d model was created including syrinx, spinal cord, cerebrospinal-fluid in subarachnoid-space, dura mater and stenosis. Pressure puls stimulation was applied to the superior surface of the subarachnoid-space fluid model simulating arterial puls of skull. Cerebrospinal-fluid has been assumed as a Newtonian fluid with laminar flow. The solid phase has been considered to be linear elastic. The fluid-solid interface was analized using ADINA software and fluid flow characteristics were extracted including velocity and pressure field as well as tissue stresses. Results show that pressure wave propagation in subarachnoid-space fluid causes the induction of motion in syrinx fluid, and stress concentration is created in spinal tissue due to the fluid cessation in syrinx and increasing local pressure, however these stress values are lower than spinal tissue strength and pressure wave propagation in this situation cannot be the main reason of syrinx development. 

Keywords

cerebrospinal-fluid hydrodynamics
finite element method
pressure wave propagation
syrinx

Subjects

[1]     N.S.J. Elliot, C.D. Betram, B.A. Martin, and Brodbelt, A.R, “Syringomyelia: A Review of the Biomechanics” Journal of Fluids and Structures, vol. 40, no. 1, pp. 1–24, July, 2013.
[2]     C.D. Bertram, “Evaluation by Fluid/Structure Interaction Spinal-Cord Simulation of the Effects of Subarachnoid-Space Stenosis on an Adjacent Syrinx”. Journal of Biomechanical Engineering, vol. 132, no. 6, pp. 061009, 2010.
[3]     C.D. Bertram, A.R. Brodbelt, and M.A. Stoodley, “The Origins of Syringomyelia: Numerical Models of Fluid/Structure Interactions in the Spinal Cord” Journal of Biomechanical Engineering, vol. 127, no. 7, pp. 1099–1109, July, 2005.
[4]     M.M. Maharaj, K. Phan, and R. Mobbs, “Spontaneous regression of post-traumatic syringomyelia: A case report and literature review” Journal of Clinical Neuroscience, vol. 44, pp. 249-253, June, 2017.
[5]     Y. Liu, “In silico Investigation of the Fluid Structure Interaction in Spinal Cord and Subarachnoid Space” MS Thesis in Mechanical Engineering, University of Illinois, Chicago, 2010.
[6]     A.F. Samdani, S.W. Hwang, A. Singla, J.T. Bennett, R.J. Ames, and J.S. Kimball, “Outcomes of patients with syringomyelia undergoing spine deformity surgery: do large syrinxes behave differently from small?” Journal of The Spine, vol. 17, pp. 1406-1411, April, 2017.
[7]     C.D. Bertram, “A Numerical Investigation of Waves Propagating in the Spinal Cord and Subarachnoid Space in the Presence of a Syrinx” Journal of Fluids and Structures, vol. 25, no. 7, pp. 1189–1205, October, 2009.
[8]     M.L. Sternberg, and M.L. Gunter, “Syringomyelia” Journal of Emergency Medicine, vol. 53, no. 2, pp. e31-e32, April, 2017.
[9]     Y. Liu, B.A. Martin, T.J. Royston, and F. Loth, “A Fluid Structure Interaction Simulation of the Cerebrospinal fluid, spinalcord, and spinal stenosis present in Syringomyelia”. Proceedings of the ASME Summer Bioengineering Conference, Grande Beach Resort, Naples Florida, USA, pp. SBC2010-19433, 2010.
[10] D. Oreskovic, M. Rados, and M. Klarica, “Review: Role of choroid plexus in cerebrospinal fluid hydrodynamics” Journal of Neuroscience, vol. 354, pp. 69-87, 2017.
[11] N.S.J. Elliot, A.D. Lucey, D.A. Lockerby, and A.R. Brodbelt, “Fluid–structure interactions in a cylindrical layered wave guide with application in the spinal column to syringomyelia” Journal of Fluids and structures, vol. 70, pp. 464-499, April, 2017.
[12] K. Bechter, P.R. Hof, and H. Benveniste, “On the flow dynamics of cerebrospinal fluid” Journal of Neurology, Psychiatry and brain Research, vol. 21, no. 2, pp. 96-103, June, 2015.
[13] S. Cheng, D. Fletcher, S. Hemley, and M. Stoodley, “Effects of fluid structure interaction in a three dimensional model of the spinal subarachnoid space”, Journal of Biomechanics, vol. 47, pp. 2826-2830, April, 2014.
[14] A. Linninger, B. Sweetman, and R. Penn, “Normal and Hydrocephalic Brain Dynamics: The Role of Reduced Cerebrospinal Fluid Reabsorption in Ventricular Enlargement”. Annals of Biomedical Engineering, vol. 37, no. 7, pp. 1434–1447, July, 2009.
Iranian Journal of Biomedical Engineering (IJBME)
Volume 10, Issue 3
Autumn 2016
Pages 223-230

  • Receive Date 03 October 2017
  • Revise Date 22 October 2017
  • Accept Date 04 October 2017

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