Iranian Journal of Biomedical Engineering (IJBME)
نشریه علمی مهندسی پزشکی زیستی

Modeling Two Delay System of Insulin-Glucose based on Noninvasive Continuous Measurement

Document Type : Full Research Paper

Authors

Reza Vosoughi 1
Armin Allahverdy 2
Sajjad Shafiekhani 1
Amir Homayoun Jafari 3

1 Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran - Research Center for Biomedical Technologies and Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran

2 Department of Radiology, Sari School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran

3 Associate Professor, Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran - Research Center for Biomedical Technologies and Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.22041/ijbme.2018.80819.1321
Abstract
In recent decades, due to the increased prevalence of diabetes and its chronic complications, glucose measurement, modeling of glucose-insulin system and glucose control have been especially important. Since the type I diabetes does not secrete insulin, cells do not absorb glucose, and thus the blood glucose level increase. In order to control your blood sugar, insulin should besubcutaneously injected into the body under complex, controlled conditions. If the level of insulin increases beyond the natural physiological range, there is a risk of death. There are various treatments for diabetes, the main treatment of which is insulin therapy. Monitoring the patient's blood sugar level continuously during the day and night is a very good treatment strategy, since it controls the patient's blood sugar level in a safe area with the lowest amount of insulin injected at the required times. This mechanism avoid the hyperglycemia (blood glucose levels greater than 120 mg/dl) and hypoglycemia (blood sugar less than 65 mg / dl). To achieve this goal, a two delay model has been developed to model blood glucose levels continuously during time. Some of the parameters of this model are estimated using the genetic algorithm to achieve the best fitness between the dynamics of the model with the experimental data obtained in this study. As a result, the developed model of this study can dynamically obtain blood glucose continuously during time, consequently it can predicts the insulin dynamics required to be injected into the patient to control the amount of blood glucose in the normal range. Therefore this controlling system is capable of preventing hypoglycemia and hyperglycemia.

Keywords

Modeling of Glucose-Insulin System
Two Delay Model
genetic algorithm

Subjects

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Iranian Journal of Biomedical Engineering (IJBME)
Volume 11, Issue 4
Winter 2018
Pages 291-301

  • Receive Date 04 February 2018
  • Revise Date 30 May 2018
  • Accept Date 03 June 2018

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