Analysis and Investigation of the Effect of Fully Covered Myosin Adsorbate Layer on Vibration of Silicon Nano Bio-Sensors for Detection of Pathogens

Hosseini-Ara, Reza; Karamrezaei, Amir Hossein; Mokhtarian, Ali

doi:10.22041/ijbme.2018.87254.1355

Document Type : Full Research Paper

Authors

¹ Assistant Professor, Department of Mechanical Engineering, Payame Noor University, Tehran, Iran

² MSc. Student, Department of Mechanical Engineering, Islamic Azad University, Khomeinishahr Branch, Khomeinishahr, Iran

³ Assistant Professor, Department of Mechanical Engineering, Islamic Azad University, Khomeinishahr Branch, Khomeinishahr, Iran

https://doi.org/10.22041/ijbme.2018.87254.1355

Abstract

This study presents a Silicon nano bio-sensor based on modified continuum mechanics model of Euler-Bernoulli beam theory. This cantilever resonant nano-sensor works based on the shift of resonant frequency due to the adsorption of very small particles such as viruses and bacteria. To this end, the surface of nano bio-sensor is impregnated into a biologically active substance such as Myosin as an adsorbate layer. However, most conducted studies have ignored the effects of mass and stiffness of this adsorbate layer and nonlocal parameter, whereas these factors play a major role in changing the resonant frequency at nano-scale and the precision of mechanical nano bio-sensors. By calculating and regarding all of the mentioned effects, in this study a Silicon nano bio-sensor with a full coverage of the adsorbate layer is precisely analyzed. The results show that the calculation of nonlocal effect reduces the resonant frequency of the nano sensor, and this effect cannot be ignored in the nano-scale. It is also observed that considering the effects of the mass and stiffness of the adsorbate layer separately, may not lead to the exact answer, but the result of both of these effects should be taken into account. In fact, simultaneously considering these effects, it reduces the resonant frequency of nano sensor, which can be useful in designing and analyzing mechanical Silicon nano bio-sensors and increasing the accuracy of their detection. Finally, for the purpose of verification assessment, the numerical results were compared with the results of other studies in the full coverage of the myosin adsorbate layer, which showed complete agreement with them.

Keywords

Main Subjects

Medical Instrumentation

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Iranian Journal of Biomedical Engineering

Analysis and Investigation of the Effect of Fully Covered Myosin Adsorbate Layer on Vibration of Silicon Nano Bio-Sensors for Detection of Pathogens

References

References

Volume 12, Issue 1
June 2018
Pages 41-49

Analysis and Investigation of the Effect of Fully Covered Myosin Adsorbate Layer on Vibration of Silicon Nano Bio-Sensors for Detection of Pathogens

References

References

Volume 12, Issue 1June 2018Pages 41-49

Volume 12, Issue 1
June 2018
Pages 41-49