نشریه علمی مهندسی پزشکی زیستی

Prediction of Sudden Cardiac Death using Time-Frequency Analysis of Electrocardiogram Signal

Document Type : Full Research Paper

Authors

1 M.Sc., Faculty of Biomedical Engineerin, Sahand University of Technology, Tabriz, Iran

2 Assistant Professor, Faculty of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran

Abstract
Sudden cardiac death (SCD) is a significant cardiovascular issue that affects approximately 3 million individuals globally each year, often occurring without any prior noticeable symptoms. The precise causes of SCD remain unclear, although ventricular fibrillation is thought to play a crucial role in its pathophysiology. Since symptoms usually appear only an hour before the event, timely prediction is essential for effective cardiac resuscitation. This study aims to predict SCD using time-frequency analysis of ECG signals. Two online datasets were utilized: the Sudden Cardiac Death Holter dataset and the MIT-BIH Normal Sinus Rhythm dataset. The proposed method involves segmenting the 60-minute interval prior to ventricular fibrillation into one-minute segments, which are then decomposed into time-frequency sub-bands using empirical mode decomposition (EMD). Nonlinear features are extracted from these decomposed signals, followed by classification using support vector machines (SVM) and K-nearest neighbors (KNN). To enhance classification accuracy, two statistical feature selection techniques, T-test and ANOVA, were employed. Results indicate that using the ANOVA feature selection method with SVM and KNN algorithms achieves high accuracy in predicting SCD. Specifically, the average accuracy rates for the 60 minutes preceding SCD were 93.51% for ANOVA-SVM and 93% for ANOVA-KNN. With T-test feature selection, the average accuracy rates were 93.29% for SVM and 93.41% for KNN. These findings demonstrate the promising performance of the proposed approach in predicting SCD.

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  1. M. Al-Khatib et al., "Preventing tomorrow's sudden cardiac death today: part I: current data on risk stratification for sudden cardiac death," American heart journal, vol. 153, no. 6, pp. 941-950, 2007.
  2. P. Zipes and H. J. Wellens, "Sudden cardiac death," Circulation, vol. 98, no. 21, pp. 2334-2351, 1998.
  3. -W. Shen, H.-P. Shen, C.-H. Lin, and Y.-L. Ou, "Detection and prediction of sudden cardiac death (SCD) for personal healthcare," in 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007: IEEE, pp. 2575-2578.
  4. Ebrahimzadeh et al., "An optimal strategy for prediction of sudden cardiac death through a pioneering feature-selection approach from HRV signal," Computer methods and programs in biomedicine, vol. 169, pp. 19-36, 2019.
  5. Khazaei, K. Raeisi, A. Goshvarpour, and M. Ahmadzadeh, "Early detection of sudden cardiac death using nonlinear analysis of heart rate variability," Biocybernetics and Biomedical Engineering, vol. 38, no. 4, pp. 931-940, 2018.
  6. Markwerth, T. Bajanowski, I. Tzimas, and R. Dettmeyer, "Sudden cardiac death—update," International journal of legal medicine, vol. 135, pp. 483-495, 2021.
  7. Rohila and A. Sharma, "Detection of sudden cardiac death by a comparative study of heart rate variability in normal and abnormal heart conditions," Biocybernetics and Biomedical Engineering, vol. 40, no. 3, pp. 1140-1154, 2020.
  8. Shi et al., "Early detection of sudden cardiac death by using ensemble empirical mode decomposition-based entropy and classical linear features from heart rate variability signals," Frontiers in Physiology, vol. 11, p. 118, 2020.
  9. Vargas-Lopez et al., "A new methodology based on EMD and nonlinear measurements for sudden cardiac death detection," Sensors, vol. 20, no. 1, p. 9, 2019.
  10. Piña-Vega, M. Valtierra-Rodriguez, C. A. Perez-Ramirez, and J. P. Amezquita-Sanchez, "Early prediction of sudden cardiac death using fractal dimension and ecg signals," Fractals, vol. 29, no. 03, p. 2150077, 2021.
  11. R. Acharya et al., "An integrated index for detection of sudden cardiac death using discrete wavelet transform and nonlinear features," Knowledge-Based Systems, vol. 83, pp. 149-158, 2015.
  12. P. Amezquita-Sanchez, M. Valtierra-Rodriguez, H. Adeli, and C. A. Perez-Ramirez, "A novel wavelet transform-homogeneity model for sudden cardiac death prediction using ECG signals," Journal of medical systems, vol. 42, no. 10, p. 176, 2018.
  13. Shi, H. Yu, and H. Wang, "Automated detection of sudden cardiac death by discrete wavelet transform of electrocardiogram signal," Symmetry, vol. 14, no. 3, p. 571, 2022.
  14. A. Centeno-Bautista, A. H. Rangel-Rodriguez, A. V. Perez-Sanchez, J. P. Amezquita-Sanchez, D. Granados-Lieberman, and M. Valtierra-Rodriguez, "Electrocardiogram analysis by means of empirical mode decomposition-based methods and convolutional neural networks for sudden cardiac death detection," Applied Sciences, vol. 13, no. 6, p. 3569, 2023.
  15. Sudden cardiac death database [Online] Available: https://physionet.org/content/sddb/1.0.0/
  16. MIT-BIH Normal Sinus Rhythm Database [Online] Available: https://physionet.org/content/nsrdb
  17. Li, W. Zhou, Q. Yuan, S. Geng, and D. Cai, "Feature extraction and recognition of ictal EEG using EMD and SVM," Computers in biology and medicine, vol. 43, no. 7, pp. 807-816, 2013.
  18. R. Guevara, L. Glass, and A. Shrier, "Phase locking, period-doubling bifurcations, and irregular dynamics in periodically stimulated cardiac cells," Science, vol. 214, no. 4527, pp. 1350-1353, 1981.
  19. P. Sturmberg and B. J. West, "Fractals in physiology and medicine," in Handbook of systems and complexity in health: Springer, 2012, pp. 171-192.
  20. Parbat and M. Chakraborty, "A novel methodology to study the cognitive load induced EEG complexity changes: Chaos, fractal and entropy based approach," Biomedical Signal Processing and Control, vol. 64, p. 102277, 2021.
  21. R. Acharya et al., "Entropies for automated detection of coronary artery disease using ECG signals: A review," Biocybernetics and Biomedical Engineering, vol. 38, no. 2, pp. 373-384, 2018.
  22. Pincus, "Approximate entropy (ApEn) as a complexity measure," Chaos: An Interdisciplinary Journal of Nonlinear Science, vol. 5, no. 1, pp. 110-117, 1995.
  23. A. Hosseini and M. B. Naghibi-Sistani, "Emotion recognition method using entropy analysis of EEG signals," International Journal of Image, Graphics and Signal Processing, vol. 3, no. 5, p. 30, 2011.
  24. K. Vidybida, "Calculating permutation entropy without permutations," Complexity, vol. 2020, pp. 1-9, 2020.
  25. J. J. Jui, R. C. Deo, P. D. Barua, A. Devi, J. Soar, and U. R. Acharya, "Application of entropy for automated detection of neurological disorders with electroencephalogram signals: A review of the last decade (2012-2022)," IEEE Access, 2023.
  26. Al-Sharhan, F. Karray, W. Gueaieb, and O. Basir, "Fuzzy entropy: a brief survey," in 10th IEEE international conference on fuzzy systems.(Cat. No. 01CH37297), 2001, vol. 3: IEEE, pp. 1135-1139.
  27. Grassberger and I. Procaccia, "Measuring the strangeness of strange attractors," Physica D: nonlinear phenomena, vol. 9, no. 1-2, pp. 189-208, 1983.
  28. C. Sprott and G. Rowlands, "Improved correlation dimension calculation," International Journal of Bifurcation and Chaos, vol. 11, no. 07, pp. 1865-1880, 2001.
  29. Katz, "A new status index derived from sociometric analysis," Psychometrika, vol. 18, no. 1, pp. 39-43, 1953.
  30. L. Weissgerber, O. Garcia-Valencia, V. D. Garovic, N. M. Milic, and S. J. Winham, "Why we need to report more than'Data were Analyzed by t-tests or ANOVA'," Elife, vol. 7, p. e36163, 2018.
  31. M. Bishop and N. M. Nasrabadi, Pattern recognition and machine learning (no. 4). Springer, 2006.
Volume 17, Issue 4
Winter 2024
Pages 285-300

  • Receive Date 29 March 2024
  • Revise Date 27 July 2024
  • Accept Date 05 August 2024