Evaluation Of Structure, Thermal Property And Drug Release Of Nano-Structure Clay (Layered Double Hydroxide) Containing Ibuprofen

Shafiei, Seyede Sara; Solati Hashjin, Mehran; Salarian, Mehrnaz

doi:10.22041/ijbme.2009.13392

Document Type : Full Research Paper

Authors

¹ PhD Student, Biomaterial Group, School of Biomedical Engineering, Amirkabir University of Technology

² Assistant Professor, School of Biomedical Engineering, Amirkabir University of Technology

³ PhD Candidate, Department of Chemical and Biochemical Engineering, University of Western Ontario

10.22041/ijbme.2009.13392

Abstract

Layered double hydroxides (LDHs) are layered solid materials having positively charged layers. A variety of negatively charged biomolecules can be hybridized with LDHs to evolve into bio-LDH Nano hybrids, including vitamins, drugs and DNA strands as well as simple organic acids. In this research, Mg-Al-LDH containing drug was synthesized by coprecipitation and anion exchange methods. The LDH structure was characterized by X-Ray Diffraction XRD, FTIR, SEM and STA techniques. The in vitro release profile of nano hybrids was analyzed by UV spectrophotometer. It was concluded that the present biocompatible hydrotalcite-like compound can be an excellent host material for encapsulating Ibuprofen and can play a role as a delivery vehicle for a controlled release.

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References

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Iranian Journal of Biomedical Engineering

Evaluation Of Structure, Thermal Property And Drug Release Of Nano-Structure Clay (Layered Double Hydroxide) Containing Ibuprofen

References

References

Volume 3, Issue 2 - Serial Number 2
June 2009
Pages 119-125

Evaluation Of Structure, Thermal Property And Drug Release Of Nano-Structure Clay (Layered Double Hydroxide) Containing Ibuprofen

References

References

Volume 3, Issue 2 - Serial Number 2June 2009Pages 119-125

Volume 3, Issue 2 - Serial Number 2
June 2009
Pages 119-125