Synthesis Of Magnesium Calcium Phosphate Nanoparticles Using Biomimetic Method In Amino Acids Environment

Kazemzadeh, Rouzbeh; Behnamghader, Ali Asghar; Hesaraki, Saeed; Hazrati, Fateme

doi:10.22041/ijbme.2009.13393

Synthesis Of Magnesium Calcium Phosphate Nanoparticles Using Biomimetic Method In Amino Acids Environment

Document Type : Full Research Paper

Authors

Rouzbeh Kazemzadeh ¹

Ali Asghar Behnamghader ²

Saeed Hesaraki ²

Fateme Hazrati ³

¹ M.Sc Student, Biomaterial Group, Materials and Energy Research Center

² Assistant Professor, Biomaterial Group, Materials and Energy Research Center

³ M.Sc Student, Biomedical Engineering School, Science and Research Branch of Islamic Azad University

https://doi.org/10.22041/ijbme.2009.13393

Abstract

Magnesium-contained Hydroxyapatite Nano powder was synthesized by wet chemical method using calcium nitrate tetra hydrate, magnesium nitrate hexa hydrate and di ammonium hydrogen phosphate in the presence of Glutamic acid. According to thermal analysis (STA) findings the samples were calcinated at specific temperatures and characterized by XRD, FTIR and TEM analysis. XRD results showed the that b-TCP ((Ca1-xMgx)3(PO4)2) was the dominant phase at 920°C. No characteristic peaks of hydroxyapatite were observed at that temperature. In contrast, the sample which was synthesized in the absence of Glutamic acid, contained both hydroxyapatite and b-TCP phase. The Findings showed a rapid decline in degree of crystallinity at 90°C with presence of Glutamic acid in reaction media. Transmission electron microscopy (TEM) observations on heat treated samples at 480°C revealed that using Glutamic acid has noticeable effect on crystallite size instead of its growth orientation. Dimensions of biomimetic nanoparticles as observed by TEM were 150x60nm and in the witness sample was 500x150nm. According to Scherrer formula for crystallite size, the size of the witness sample was calculated about 40nm. However, because of low degree of crystallinity it was impossible to calculate the size of Glutamic contained samples.

Keywords

Magnesium Hydroxyapatite

Magnesium Calcium Phosphate

nanoparticles

Glutamic Acid

Biomimetic

Subjects

Nano-Biomaterials

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