Document Type : Full Research Paper


1 Ph.D. Student, CIPCE, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran / Visiting Ph.D. Student, Seaman Family MR Research Centre, University of Calgary, Calgary, Alberta, Canada

2 Professor, CIPCE, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran / Senior Scientist, Image Analysis Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI, USA

3 Professor, CIPCE, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran

4 Professor, Pars Advanced Medical Research Center, Pars Hospital, Tehran, Iran

5 Professor, Isfahan Neurosciences Research Center, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


Since electroencephalography (EEG) signal contains temporal information and fMRI carries spatial information, we can reasonably expect that a combination of the two contributes greatly to precise localization of   epileptic focuses.  With that in mind, we have first extracted spike patterns from outside of scanner EEG, through detecting and averaging the interictal epileptiform discharges (IED). Then, having implemented the correlation between the identified pattern and inside-scanner EEG, an automated system was developed to extract the temporal information when an epileptic seizure is triggered. We proceeded to convolve the obtained regressor with the hemodynamic response function (HRF) using the general linear model (GLM) for the purpose of localizing the epileptic focus.  This study was conducted on 6 medication-resistant patients with epilepsy whose data was recorded in the National Brain Mapping Lab (NBML). The results of the proposed method are in line with the information provided in EEG for each of the 6 patients, and for the 4 patients who were candidates for brain surgery, they provided further information. The results suggest a significant improvement in localization accuracy and precision compared to existing methods in the literature.


Main Subjects

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