نشریه‌ی علمی مهندسی پزشکی زیستی

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بررسی تاثیر ضریب نفوذ بر انتقال جرم ذرات لیپوپروتئین با چگالی کم در شریان کاروتید با دیواره‌ی چند لایه

نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 استادیار، گروه مهندسی پزشکی، دانشکده‌ی فنی و مهندسی، دانشگاه اصفهان، اصفهان

2 دانشجوی کارشناسی ارشد مهندسی پزشکی، گروه مهندسی پزشکی، دانشکده‌ی فنی و مهندسی، دانشگاه اصفهان، اصفهان

3 دانشجوی دکتری مهندسی پزشکی، دانشگاه منچستر، کانادا

چکیده

بیماری آترواسکلروسیس، شایع­ترین بیماری قلبی عروقی است که در شریان­های بزرگ و یا متوسط اتفاق می­افتد. مهمترین پیامد این بیماری تشکیل پلاکت­های شریانی در مکان­هایی است که در آن‌جا علاوه بر آسیب شریانی، غلظت موادی نظیر  لیپوپروتئین­های با چگالی کم (LDL) افزایش یافته است. پلاکت­های ایجاد شده نه تنها مانع خون‌رسانی مناسب به بافت­های پایین دست پلاکت می­شوند بلکه در مراحل پیشرفته، پارگی و یا سایش پلاکت می­تواند موجب ایجاد لخته و نهایتا سکته‌ی قلبی یا مغزی شود. در این پژوهش به منظور بررسی دقیق‌تر نحوه‌ی انباشت لیپوپروتئین­های با چگالی کم در ناحیه‌ی مجرا و دیواره‌ی شریان کاروتید، به حل عددی انتقال جرم ذرات LDL با استفاده از مدل دیواره‌ی چند لایه و ضریب نفوذ وابسته به نرخ برش پرداخته شده است. دیواره‌های رگ به عنوان جسم متخلخل  و صلب فرض شده، و معادلات ناویر-استوکس، انتقال جرم و دارسی با درنظر گرفتن رفتار غیرنیوتنی خون در ناحیه‌ی مجرای شریان و لایه­های مختلف  دیواره‌ی رگ با  روش عددی  حل شده‌اند. در این مقاله تاثیر ثابت یا متغیر بودن ضریب نفوذ، تاثیر رفتار غیرنیوتنی خون، تاثیر رفتار غیرنیوتنی پلاسما و تاثیر فشار خون بر میزان انباشت ذرات LDL در ناحیه‌ی مجرا و لایه­های دیواره‌ی شریان کاروتید  مورد بررسی قرار گرفته است. نتایج نشان دادند که متغیر بودن ضریب نفوذ در ناحیه‌ی مجرای شریان و نیز رفتار غیرنیوتنی پلاسما در ناحیه‌ی دیواره‌ی شریان می‌توانند تاثیر قابل ملاحظه‌ای در نتایج به‌دست آمده برای انباشت ذرات LDL  داشته باشند. هم‌چنین افزایش فشار خون نه تنها موجب انباشت بیشتر ذرات LDL در مرز بین خون و دیواره‌ی شریان­ بل‌که انباشت بیشتر این ذرات در لایه­های مختلف دیواره‌ی شریان­ می­شود که خود احتمال شکل‌گیری بیماری آترواسکلروسیس را افزایش می­دهد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Investigation of the Effect of Diffusion Coefficient on Low Density Lipoprotein Particles Mass Transport within a Carotid Artery with Multilayer Wall

نویسندگان [English]

  • Mohsen Rabbani 1
  • Mahmood Reza Sadeghi 1
  • Parisa Golmohammadi 2
  • Amin Deyranlou 3

1 Assistant Professor, Biomedical Engineering Department, Engineering Faculty, University of Isfahan, Isfahan, Iran

2 MSc Student, Biomedical Engineering Department, Engineering Faculty, University of Isfahan, Isfahan, Iran

3 PhD Student, Mechanical Engineering, University of Manchester, UK

چکیده [English]

The atherosclerosis disease is the most prevalent illness that occurs in large or medium size arteries. The most important consequence of this disease is creation of arterial platelets in places where in addition to artery damages; the density of materials such as low density lipoprotein (LDL) is being increased.  The produced platelets not only block appropriate blood delivery to downstream fibers but also in advanced stages, rubbing or tearing platelet could bring about clot and eventually heart or brain stroke. In this research, in order to review the procedure of LDLs accumulation within lumens and arterial wall, numerical simulation of LDL particles mass transport by using several layer model and diffusion coefficient depending on shear rate are used. Arteries’ walls are assumed to be porous and rigid. In this study, Navier–Stokes equations, mass transport, and Darsi have been solved by numerical methods with regarding to non-Newtonian behavior of blood in lumens and different layers of vessel’s wall. In this article, the impacts of diffusion coefficient being constant or variable, impact of non-Newtonian behavior of blood, impact of non-Newtonian behavior of plasma and impact of blood pressure on the amount of LDL accumulation in lumen and layers of carotid artery are reviewed. The results indicate that diffusion coefficient variation in arterial lumen and non-Newtonian behavior of plasma within the arterial wall could affect significantly on LDL accumulation. In addition, increasing blood pressure not only increases LDL accumulation on interface of blood and arterial wall but also increases the accumulation within arterial wall layers and consequently the artery is more susceptible to atherosclerosis development.  

کلیدواژه‌ها [English]

  • Atherosclerosis
  • Low Density Lipoprotein (LDL)
  • Carotid Artery
  • Variable Diffusion Coefficient
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نشریه‌ی علمی مهندسی پزشکی زیستی
دوره 11، شماره 2
مرداد 1396
صفحه 137-151
فایل ها
سابقه مقاله
  • تاریخ دریافت: 12 مهر 1396
  • تاریخ بازنگری: 12 آذر 1396
  • تاریخ پذیرش: 05 دی 1396
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