Iranian Journal of Biomedical Engineering (IJBME)

پیش‌بینی مرگ ناگهانی قلبی با استفاده از تحلیل زمان-فرکانسی سیگنال الکتروکاردیوگرام

نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 کارشناسی ارشد، گروه بیوالکتریک، دانشکده‌ی مهندسی پزشکی، دانشگاه صنعتی سهند، تبریز، ایران

2 استادیار، گروه بیوالکتریک، دانشکده‌ی مهندسی پزشکی، دانشگاه صنعتی سهند، تبریز، ایران

چکیده
مرگ ناگهانی قلبی (SCD) یک عارضه‌ی مهم قلبی عروقی است که سالانه حدود 3 میلیون نفر را در سراسر جهان تحت تاثیر قرار داده و اغلب بدون علائم قابل مشاهده‌ی قبلی رخ می‌دهد. علل دقیق SCD هنوز مشخص نیست، اگر چه فیبریلاسیون بطنی به عنوان یک عامل اصلی در پاتوفیزیولوژی آن شناخته می‌شود. با توجه به این که علائم معمولا تنها یک ساعت قبل از وقوع حادثه ظاهر می‌شوند، پیش­بینی به موقع برای احیای موثر قلبی ضروری است. این مطالعه به منظور پیش‌بینی SCD از تحلیل زمان-فرکانس سیگنال‌های ECG انجام شده است. در این پژوهش از دو مجموعه‌ی داده‌ی آنلاین هولتر مرگ ناگهانی قلبی و ریتم سینوسی نرمال MIT-BIH استفاده شده است. روش پیشنهادی شامل تقسیم بازه‌ی 60 دقیقه‌ای قبل از فیبریلاسیون بطنی به بخش‌های 1 دقیقه‌ای است که سپس با استفاده از تجزیه‌ی حالت تجربی (EMD) به باندهای زیرزمان-فرکانس تفکیک شده‌اند. ویژگی‌های غیرخطی از این سیگنال‌های تجزیه شده استخراج گردیده و سپس طبقه‌بندی با استفاده از ماشین‌های بردار پشتیبان (SVM) و k نزدیک‌ترین همسایگان (KNN) انجام شده است. برای بهبود صحت، دو تکنیک انتخاب ویژگی آماری T-test و ANOVA به کار گرفته شده است. نتایج نشان می‌دهد که استفاده از روش انتخاب ویژگی ANOVA همراه با الگوریتم‌های SVM و KNN به صحت بالایی در پیش‌بینی SCD دست یافته است. به طور خاص صحت متوسط در 60 دقیقه قبل از SCD برای روش‌های ANOVA-SVM و ANOVA-KNN به ترتیب برابر با 51/93% و 93% است. با استفاده از انتخاب ویژگی T-test صحت متوسط برای روش‌های SVM و KNN به ترتیب برابر با 29/93% و 41/93% است. این یافته‌ها عمل‌کرد امیدوار کننده‌ی روش پیشنهادی در پیش‌بینی SCD را نشان می‌دهد.

کلیدواژه‌ها

موضوعات


عنوان مقاله English

Prediction of Sudden Cardiac Death using Time-Frequency Analysis of Electrocardiogram Signal

نویسندگان English

Fatemeh Danesh Jablo 1
Hamed Danandeh Hesar 2
1 M.Sc., Faculty of Biomedical Engineerin, Sahand University of Technology, Tabriz, Iran
2 Assistant Professor, Faculty of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran
چکیده English

Sudden cardiac death (SCD) is a significant cardiovascular issue that affects approximately 3 million individuals globally each year, often occurring without any prior noticeable symptoms. The precise causes of SCD remain unclear, although ventricular fibrillation is thought to play a crucial role in its pathophysiology. Since symptoms usually appear only an hour before the event, timely prediction is essential for effective cardiac resuscitation. This study aims to predict SCD using time-frequency analysis of ECG signals. Two online datasets were utilized: the Sudden Cardiac Death Holter dataset and the MIT-BIH Normal Sinus Rhythm dataset. The proposed method involves segmenting the 60-minute interval prior to ventricular fibrillation into one-minute segments, which are then decomposed into time-frequency sub-bands using empirical mode decomposition (EMD). Nonlinear features are extracted from these decomposed signals, followed by classification using support vector machines (SVM) and K-nearest neighbors (KNN). To enhance classification accuracy, two statistical feature selection techniques, T-test and ANOVA, were employed. Results indicate that using the ANOVA feature selection method with SVM and KNN algorithms achieves high accuracy in predicting SCD. Specifically, the average accuracy rates for the 60 minutes preceding SCD were 93.51% for ANOVA-SVM and 93% for ANOVA-KNN. With T-test feature selection, the average accuracy rates were 93.29% for SVM and 93.41% for KNN. These findings demonstrate the promising performance of the proposed approach in predicting SCD.

کلیدواژه‌ها English

Sudden Cardiac Death
Electrocardiogram Signal
Empirical Mode Decomposition
Nonlinear Feature Extraction
  1. M. Al-Khatib et al., "Preventing tomorrow's sudden cardiac death today: part I: current data on risk stratification for sudden cardiac death," American heart journal, vol. 153, no. 6, pp. 941-950, 2007.
  2. P. Zipes and H. J. Wellens, "Sudden cardiac death," Circulation, vol. 98, no. 21, pp. 2334-2351, 1998.
  3. -W. Shen, H.-P. Shen, C.-H. Lin, and Y.-L. Ou, "Detection and prediction of sudden cardiac death (SCD) for personal healthcare," in 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007: IEEE, pp. 2575-2578.
  4. Ebrahimzadeh et al., "An optimal strategy for prediction of sudden cardiac death through a pioneering feature-selection approach from HRV signal," Computer methods and programs in biomedicine, vol. 169, pp. 19-36, 2019.
  5. Khazaei, K. Raeisi, A. Goshvarpour, and M. Ahmadzadeh, "Early detection of sudden cardiac death using nonlinear analysis of heart rate variability," Biocybernetics and Biomedical Engineering, vol. 38, no. 4, pp. 931-940, 2018.
  6. Markwerth, T. Bajanowski, I. Tzimas, and R. Dettmeyer, "Sudden cardiac death—update," International journal of legal medicine, vol. 135, pp. 483-495, 2021.
  7. Rohila and A. Sharma, "Detection of sudden cardiac death by a comparative study of heart rate variability in normal and abnormal heart conditions," Biocybernetics and Biomedical Engineering, vol. 40, no. 3, pp. 1140-1154, 2020.
  8. Shi et al., "Early detection of sudden cardiac death by using ensemble empirical mode decomposition-based entropy and classical linear features from heart rate variability signals," Frontiers in Physiology, vol. 11, p. 118, 2020.
  9. Vargas-Lopez et al., "A new methodology based on EMD and nonlinear measurements for sudden cardiac death detection," Sensors, vol. 20, no. 1, p. 9, 2019.
  10. Piña-Vega, M. Valtierra-Rodriguez, C. A. Perez-Ramirez, and J. P. Amezquita-Sanchez, "Early prediction of sudden cardiac death using fractal dimension and ecg signals," Fractals, vol. 29, no. 03, p. 2150077, 2021.
  11. R. Acharya et al., "An integrated index for detection of sudden cardiac death using discrete wavelet transform and nonlinear features," Knowledge-Based Systems, vol. 83, pp. 149-158, 2015.
  12. P. Amezquita-Sanchez, M. Valtierra-Rodriguez, H. Adeli, and C. A. Perez-Ramirez, "A novel wavelet transform-homogeneity model for sudden cardiac death prediction using ECG signals," Journal of medical systems, vol. 42, no. 10, p. 176, 2018.
  13. Shi, H. Yu, and H. Wang, "Automated detection of sudden cardiac death by discrete wavelet transform of electrocardiogram signal," Symmetry, vol. 14, no. 3, p. 571, 2022.
  14. A. Centeno-Bautista, A. H. Rangel-Rodriguez, A. V. Perez-Sanchez, J. P. Amezquita-Sanchez, D. Granados-Lieberman, and M. Valtierra-Rodriguez, "Electrocardiogram analysis by means of empirical mode decomposition-based methods and convolutional neural networks for sudden cardiac death detection," Applied Sciences, vol. 13, no. 6, p. 3569, 2023.
  15. Sudden cardiac death database [Online] Available: https://physionet.org/content/sddb/1.0.0/
  16. MIT-BIH Normal Sinus Rhythm Database [Online] Available: https://physionet.org/content/nsrdb
  17. Li, W. Zhou, Q. Yuan, S. Geng, and D. Cai, "Feature extraction and recognition of ictal EEG using EMD and SVM," Computers in biology and medicine, vol. 43, no. 7, pp. 807-816, 2013.
  18. R. Guevara, L. Glass, and A. Shrier, "Phase locking, period-doubling bifurcations, and irregular dynamics in periodically stimulated cardiac cells," Science, vol. 214, no. 4527, pp. 1350-1353, 1981.
  19. P. Sturmberg and B. J. West, "Fractals in physiology and medicine," in Handbook of systems and complexity in health: Springer, 2012, pp. 171-192.
  20. Parbat and M. Chakraborty, "A novel methodology to study the cognitive load induced EEG complexity changes: Chaos, fractal and entropy based approach," Biomedical Signal Processing and Control, vol. 64, p. 102277, 2021.
  21. R. Acharya et al., "Entropies for automated detection of coronary artery disease using ECG signals: A review," Biocybernetics and Biomedical Engineering, vol. 38, no. 2, pp. 373-384, 2018.
  22. Pincus, "Approximate entropy (ApEn) as a complexity measure," Chaos: An Interdisciplinary Journal of Nonlinear Science, vol. 5, no. 1, pp. 110-117, 1995.
  23. A. Hosseini and M. B. Naghibi-Sistani, "Emotion recognition method using entropy analysis of EEG signals," International Journal of Image, Graphics and Signal Processing, vol. 3, no. 5, p. 30, 2011.
  24. K. Vidybida, "Calculating permutation entropy without permutations," Complexity, vol. 2020, pp. 1-9, 2020.
  25. J. J. Jui, R. C. Deo, P. D. Barua, A. Devi, J. Soar, and U. R. Acharya, "Application of entropy for automated detection of neurological disorders with electroencephalogram signals: A review of the last decade (2012-2022)," IEEE Access, 2023.
  26. Al-Sharhan, F. Karray, W. Gueaieb, and O. Basir, "Fuzzy entropy: a brief survey," in 10th IEEE international conference on fuzzy systems.(Cat. No. 01CH37297), 2001, vol. 3: IEEE, pp. 1135-1139.
  27. Grassberger and I. Procaccia, "Measuring the strangeness of strange attractors," Physica D: nonlinear phenomena, vol. 9, no. 1-2, pp. 189-208, 1983.
  28. C. Sprott and G. Rowlands, "Improved correlation dimension calculation," International Journal of Bifurcation and Chaos, vol. 11, no. 07, pp. 1865-1880, 2001.
  29. Katz, "A new status index derived from sociometric analysis," Psychometrika, vol. 18, no. 1, pp. 39-43, 1953.
  30. L. Weissgerber, O. Garcia-Valencia, V. D. Garovic, N. M. Milic, and S. J. Winham, "Why we need to report more than'Data were Analyzed by t-tests or ANOVA'," Elife, vol. 7, p. e36163, 2018.
  31. M. Bishop and N. M. Nasrabadi, Pattern recognition and machine learning (no. 4). Springer, 2006.
دوره 17، شماره 4
زمستان 1402
صفحه 285-300

  • تاریخ دریافت 10 فروردین 1403
  • تاریخ بازنگری 06 مرداد 1403
  • تاریخ پذیرش 15 مرداد 1403