نشریه علمی مهندسی پزشکی زیستی
Iranian Journal of Biomedical Engineering (IJBME)

تغییرات توپولوژی سراسری مغز در افراد مبتلا به اختلال مصرف مت‌آمفتامین

نوع مقاله : مقاله کامل پژوهشی

نویسندگان

علیرضا طالش جفادیده 1
صادق قادری 2

1 استادیار، گروه مهندسی ورزش، دانشکده‌ی علوم مهندسی، دانشکدگان فنی، دانشگاه تهران، تهران، ایران

2 دکتری تخصصی، پژوهشکده‌ی علوم شناختی و مغز، دانشگاه شهید بهشتی، تهران، ایران

https://doi.org/10.22041/ijbme.2024.2028380.1899
چکیده
در طول بیست سال گذشته، اختلال مصرف مت‌آمفتامین (MUD) به یک چالش مهم بهداشت عمومی تبدیل شده و میزان شیوع آن تا سطوح اپیدمی افزایش یافته است. درک تغییرات عمل‌کردی مغز افراد MUD می‌تواند راه را برای تشخیص زودهنگام و دقیق‌تر، توسعه‌ی درمان‌های موثرتر، رویکردهای پیش‌گیرانه و ترویج بهبودی طولانی‌مدت هموار کند. از این رو در این مطالعه معیارهای سراسری گراف حاصل از ارتباطات عمل‌کردی گروه MUD با گروه کنترل (HC) مقایسه شده است تا وجود یا عدم وجود تغییرات در توپولوژی ارتباطات عمل‌کردی مغزی افراد MUD مشخص شود. در بیان جزئی‌تر، داده‌ی EEG در حالت استراحت (با چشمان باز) 17 شرکت کننده‌ی MUD و 14 شرکت کننده‌ی HC که از لحاظ سن و جنسیت تفاوت معنی‌داری با گروه MUD نداشتند ثبت و پیش‌پردازش شده است. برای هر فرد، ماتریس ارتباطات عمل‌کردی با روش wPLI و برای هر یک از 9 باند فرکانسی دلتا، تتا، آلفا1، آلفا2، بتا1، بتا2، بتا3، بتا4 و گاما محاسبه شده است. معیارهای سراسری گراف شامل کارآمدی، خروج از مرکز، شعاع، قطر، ضریب دسته‌بندی، ضریب خوشه‌بندی، مرکزیت بردار ویژه، مدولار بودن، مرکزیت بینابینی و درجه از هر ماتریس استخراج گردیده است. نتایج آماری معنی‌دار در فرکانس‌های بالا یعنی بتا 4 (25-30 هرتز) و گاما (30-45 هرتز) پیدا شده است. معیارهای کارآمدی، ضریب خوشه‌بندی، مدولار بودن، مرکزیت بینابینی و درجه برای گروه MUD و معیارهای خروج از مرکز و شعاع برای گروه HC بیش‌تر بوده است. این نتایج ممکن است نشان دهنده‌ی اختلال در تعادل بین تفکیک و یک‌پارچگی عمل‌کردهای مغزی گروه MUD باشد. هم‌چنین این معیارهای عنوان شده با نمرات مربوط به تکانش‌گری نیز همبستگی معنی‌داری داشته‌اند. نتایج این مطالعه نشان می‌دهد که مصرف مت‌آمفتامین می‌تواند بر توپولوژی سراسری حاکم بر ارتباطات عمل‌کردی مغز تاثیر بگذارد که این امر به نوبه خود ممکن است باعث تکانش‌گری بیش‌تر مصرف کنندگان گردد. این مطالعه، انجام مطالعات بیش‌تر در مورد اثرات MUD بر توپولوژی سراسری مغز را توجیه می‌کند. 

کلیدواژه‌ها

اختلال مصرف مت‌آمفتامین
افراد سالم کنترل
الکتروانسفالوگرافی
ارتباطات عمل‌کردی
معیارهای سراسری گراف

موضوعات

عنوان مقاله English

Brain Global Topology Alternations in Methamphetamine Use Disorders

نویسندگان English

Alireza Talesh Jafadideh 1
Sadegh Ghaderi 2
1 Assistant Professor, Biomedical Engineering, School of Engineering Science, College of Engineering, University of Tehran, Tehran, Iran
2 Ph.D., Institute for Cognitive & Brain Sciences, Shahid Beheshti University, Tehran, Iran
چکیده English

Over the past twenty years, methamphetamine use disorder (MUD) has become a significant public health challenge, with prevalence rates soaring to epidemic levels. Understanding the brain functional changes of MUD subjects can pave the way for earlier and more accurate diagnosis, development of more effective treatments, preventative strategies, and promote long-term recovery. Hence, in this study, the graph global metrics were extracted from functional connectivity matrices of the MUD and healthy controls (HC) groups and compared between two groups in order to find out if there are changes in the brain global topology of the MUD subjects. In a detailed explanation, resting-state electroencephalography (EEG) data (with eyes open) of 14 MUD participants and 17 age and sex matched HCs were recorded and preprocessed. For each individual, the functional connectivity matrix was calculated using the wPLI method in Delta, Theta, Alpha I, Alpha II, Beta I, Beta II, Beta III, Beta IV, and Gamma frequency bands. From each connectivity matrix, 10 global metrics of graph, including global efficiency, eccentricity, radius, diameter, assortativity coefficient, clustering coefficient, eigenvector centrality, modularity, betweenness centrality, and degree, were extracted. Statistically significant changes in brain global topology of MUD subjects were found in high frequencies, i.e., Beta IV (25-30 Hz) and Gamma (30-45 Hz). The efficiency, clustering coefficient, modularity, betweenness centrality, and degree were higher for MUDs whereas the eccentricity and radius were higher for HCs. These changes may reflect disrupted balance between segregation and integration of brain function in MUD subjects. Also, these significant metrics showed significant correlations with impulsivity scores. The observed results in this study demonstrate that methamphetamines can affect global topology of functional connectivity, which in turn may lead to more impulsivity of MUD subjects. This study justifies further studies into the effects of MUD on brain global topology.

کلیدواژه‌ها English

Methamphetamine Use Disorder
Healthy Controls
Electroencephalography
Functional Connectivity
Graph Global Metrics
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نشریه علمی مهندسی پزشکی زیستی
دوره 17، شماره 4
زمستان 1402
صفحه 331-349

  • تاریخ دریافت 17 اردیبهشت 1403
  • تاریخ بازنگری 07 شهریور 1403
  • تاریخ پذیرش 19 شهریور 1403

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