نوع مقاله : مقاله کامل پژوهشی
نویسندگان
1 کارشناسی ارشد، گروه مهندسی پزشکی، دانشکدهی فنی مهندسی، دانشگاه شاهد، تهران، ایران
2 دانشیار، گروه مهندسی پزشکی، دانشکدهی فنی مهندسی، دانشگاه شاهد، تهران، ایران
چکیده
بیماری پارکینسون یک اختلال عصبی است که به طور عمده بر نورونهای تولید کنندهی دوپامین تاثیر گذاشته و موجب اختلال در سیستم حرکتی میشود. بارزترین علایم این بیماری شامل لرزش، حرکت آهسته، سفتی و دشواری در راه رفتن است. راه رفتن بیماران پارکینسون با کندی در حرکت همراه است. در این مقاله با استفاده از روشهای ریاضی و کامپیوتری، راه رفتن بیماران پارکینسون مدل‌سازی شده است. این مدل متشکل از ساختارهای درگیر در بیماری پارکینسون بوده که از مغز شروع شده و تا مفصل زانو ادامه دارد و شامل عقدههای قاعدهای، تالاموس، کورتکس، ناحیه‌ی موتوری تکمیلی (SMA)، عضله و مفصل میباشد. خروجی مدل به صورت سرعت راه رفتن در بیماران پارکینسون بوده و برابر با 83/0 m/s به دست آمده است که در محدودهی گزارش شده توسط نتایج کلینیکی (18/0 – 21/1 m/s) قرار دارد. در این مطالعه روشهایی برای افزایش سرعت راه رفتن در بیماران پارکینسون مورد بررسی قرار گرفته که شامل تحریک عمقی مغز، استفاده از دارو و تقویت عضله است. نتایج نشان میدهد که هر یک از این روشها موجب بهبود سرعت راه رفتن شده است. در واقع با به کارگیری این روشها روی مدل، مقدار خروجی افزایش یافته و به محدودهی سرعت راه رفتن در افراد سالم (30/1 – 36/1 m/s) نزدیک شده است. هم‌چنین اثر سفتی روی سرعت راه رفتن مورد مطالعه قرار گرفته و مشاهده شده است که سفتی عضلانی با سرعت رابطهی عکس دارد. در پایان نیز یک روش کنترلی برای بهبود سرعت پیشنهاد شده که با افزایش پاسخ سیستم حلقه بسته موجب افزایش سرعت راه رفتن شده است.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
Modeling Parkinsonian Gait and Investigating some Approaches to Increase the Gait Speed
نویسندگان [English]
- Seyede Fatemeh Ghoreishian Amiri 1
- Mohammad Pooyan 2
1 M.Sc., Department of Biomedical Engineering, Faculty of Engineering, Shahed University, Tehran, Iran
2 Associate Professor, Department of Biomedical Engineering, Faculty of Engineering, Shahed University, Tehran, Iran
چکیده [English]
Parkinson's disease (PD) is a neurological disorder that mainly affects dopamine-producing neurons and motor system. The most obvious symptoms of PD are tremor, slow movement, stiffness and difficulty with walking. Walking in PD is slower than normal walking. In this paper, the gait in patients with PD is modeled by a mathematical and computational method. This model includes structures which are involved in PD, such as basal ganglia, thalamus, cortex, supplementary motor area (SMA), muscle and joint-load dynamics. The output of the model is walking speed in PD. The output value is 0.83 m/s, which is in the range reported by clinical results (0.18-1.21 m/s). Some methods which increase the gait speed in PD are investigated too. These methods include deep brain stimulation, drug prescription and strengthening the muscles. The results show that each of these methods will improve the gait speed, in fact, by using these methods, the value of output increases and approaches the walking speed range in healthy individuals (1.36-1.30 m/s). Moreover, the effect of rigidity on gait speed is studied; it has been observed that the stiffness and speed of the gait are inversely related. Finally a control method is offered which improve the gait speed by increasing the magnitude response of the closed-loop system.
کلیدواژه‌ها [English]
- Parkinson’s Disease
- Modeling
- Gait Speed
- Improving
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