نشریه علمی مهندسی پزشکی زیستی
Iranian Journal of Biomedical Engineering (IJBME)

تحلیل عددی اثر تومور روی جریان هوا و مجرای تنفسی در سیستم تنفس فوقانی انسان

نوع مقاله : مقاله کامل پژوهشی

نویسندگان

گلبرگ السادات معتمدی 1
شاهرخ شجاعی 2
کامران حسنی 3

1 دانشجوی دکتری، گروه مهندسی پزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 استادیار، گروه مهندسی پزشکی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران

3 دانشیار، گروه مهندسی پزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

https://doi.org/10.22041/ijbme.2023.1972138.1812
چکیده
همواره اثرات تغییرات ساختاری تومور بر مسیر هوای تنفسی مورد توجه محققان بوده است. این اثرات در موارد حاد منجر به خفگی بیمار خواهد شد. در این مطالعه به کمک نرم‌افزار انسیس یک مدل محاسباتی برای بررسی اثر تومور روی جریان هوا در ناحیه‌ی حنجره ارائه شده است. این مدل قادر است اثر حضور تومور بر سرعت و فشار هوا در سیستم هوایی فوقانی را به کمک شبیه‌سازی کامپیوتری محاسبه کند. در این پژوهش شبیه‌سازی جریان هوای پایا برای بازدم در سه دبی تنفسی 15، 26 و 30 L/min انجام شده است. بیش‌ترین حد سرعت در سه دبی تنفسی 15، 26 و 30 L/min به ترتیب معادل 26/6، 58/10 و 14/12 m/s در حنجره مشاهده شده است. هم‌چنین بیش‌ترین فشار در نای رخ داده به طوری که ماکسیمم فشار در سه دبی تنفسی 15، 26 و 30 L/min به ترتیب برابر با 6/19، 01/51 و 8/65 Pa است. از سوی دیگر بیش‌ترین تغییر شکل در ناحیه‌ی تنگ‌شدگی مجرای تنفسی روی داده است. هم‌چنین با افزایش نرخ جریان میزان تغییر شکل نیز افزایش یافته است. ماکسیمم تغییر شکل روی جدار در سه دبی تنفسی 15، 26 و 30 L/min به ترتیب برابر با 07/0، 2/0 و 27/0 mm است. در این مدل تنفسی به دلیل حضور تومور، سرعت و تنش برشی روی جداره به بیش‌ترین میزان خود در ناحیه‌ی حنجره رسیده است. حضور تومور می‌تواند به مرور زمان منجر به مسدود شدن مسیر هوا و خفگی بیمار شود. هم‌چنین خطر انسداد راه هوایی حتی در کاهش جزئی ظرفیت تنفسی افزایش می‌یابد. ارائه‌ی یک مدل عددی برای سیستم تنفسی می‌تواند در راستای رویکرد درمانی بهتر موثر باشد.

کلیدواژه‌ها

مدل عددی
سیستم تنفس فوقانی
تومور
تغییر شکل

موضوعات

عنوان مقاله English

Numerical Analysis of Tumor Effect on Airflow and Respiratory Tract in the Human Upper Respiratory System

نویسندگان English

Golbargalsadat Motamedi 1
Shahrokh Shojaei 2
Kamran Hassani 3
1 Ph.D. Student, Department of Biomedical Engineering, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
2 Assistant Professor, Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
3 Associate Professor, Department of Biomedical Engineering, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
چکیده English

The pathological effects of the tumor on the respiratory airway have always been the focus of researchers. So, these effects will lead to the suffocation of the patient in acute cases. This study presents a computational model to investigate the effect of a tumor on the airflow in the larynx area with the help of Ansys software. The presented model is able to numerically calculate the effect of tumor presence on airspeed and pressure in the upper air system. This study considered the simulation of steady airflow for exhalation in three respiratory flow rates of 15 L/min, 26 L/min, and 30 L/min. The maximum speed limit in the respiratory flow of L/min 15, L/min 26, and L/min 30, respectively, 6.26 m/s, 10.58 m/s, and 12.14 m/s, appears in the larynx. Also, the highest pressure occurs in the trachea, so the maximum pressure in the respiratory rate is 15 L/min, 26 L/min, and 30 L/min, respectively, equal 19.6 Pa, 51.01 Pa, and 65.8 Pa. On the other hand, most deformation occurs in the area of ​​narrowing of the respiratory tract. With the increase in the flow rate, the amount of deformation also increases. The maximum deformation on the wall at the respiratory flow rate of 15 L/min, 26 L/min, and 30 L/min is equal to 0.07mm, 0.2mm, and 0.27mm, respectively. Due to the presence of a tumor in this respiratory model, velocity and WSS reach their maximum in the larynx region. The presence of a tumor can gradually lead to airway obstruction. Moreover, the risk of airway obstruction increases even in a slight reduction in respiratory capacity. Providing a numerical model for the respiratory system can effectively lead to a better treatment approach.

کلیدواژه‌ها English

Numerical Model
Upper Respiratory System
Tumor
Deformation
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نشریه علمی مهندسی پزشکی زیستی
دوره 16، شماره 4
زمستان 1401
صفحه 309-319

  • تاریخ دریافت 29 آبان 1401
  • تاریخ بازنگری 26 تیر 1402
  • تاریخ پذیرش 07 مرداد 1402

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